The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

Zelin Li,1,2 Fei Wang,1,2 Yujiao Jia,1,2 Feiyue Guo,1,3 Shuchun Chen1,2,4 1Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 3Departm...

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Autores principales:	Li Z, Wang F, Jia Y, Guo F, Chen S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hemoglobin glycation variation index vitamin d type 2 diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d84f2e9960ab4e78b913668b711ca7dc
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spelling	oai:doaj.org-article:d84f2e9960ab4e78b913668b711ca7dc2021-12-02T13:45:25ZThe Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/d84f2e9960ab4e78b913668b711ca7dc2021-04-01T00:00:00Zhttps://www.dovepress.com/the-relationship-between-hemoglobin-glycation-variation-index-and-vita-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Zelin Li,1,2 Fei Wang,1,2 Yujiao Jia,1,2 Feiyue Guo,1,3 Shuchun Chen1,2,4 1Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Glandular Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 4Hebei Key Laboratory of Metabolic Diseases, Hebei, People’s Republic of ChinaCorrespondence: Shuchun ChenDepartment of Endocrinology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaTel +86 31185988406Fax +86 31185988406Email chenshuc2014@163.comObjective: This study aimed to investigate the relationship between hemoglobin glycation variation index (HGI) and vitamin D in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: This is a cross-sectional study that recruited 347 patients with T2DM. The subjects were divided into no vitamin D deficiency group (25(OH)D ≥ 20 ng/mL) and vitamin D deficiency group (25(OH)D < 20 ng/mL). HGI was calculated as the difference between the measured and predicted values of HbA1c using the linear relationship between HbA1c level and fasting plasma glucose levels. All study participants were divided into high HGI and low HGI groups using the median of HGI as the boundary. At last, the subjects were divided into male group and female group, and these groups were further subdivided into vitamin D deficiency group and no vitamin D deficiency group.Results: The levels of HGI were significantly higher in the vitamin D deficiency group compared with the no vitamin D deficiency group for all patients. The same was true for female patients but not for male patients. The prevalence of vitamin D deficiency in the high HGI group was higher than that in the low HGI group. The high HGI group had lower vitamin D levels compared to the low HGI group. Compared to the male group, the female group had lower vitamin D levels but higher HGI levels. A negative correlation existed between 25(OH) D and HGI in all subjects, as well as in the female-only subgroups. In the male-only subgroups, there was no correlation between them, and this positive correlation still existed after adjusting for other factors in multilinear regression analysis.Conclusion: Our study showed for the first time that HGI is inversely associated with vitamin D in all patients with T2DM, and the correlation was also found in female patients, but not in male patients.Keywords: hemoglobin glycation variation index, vitamin D, type 2 diabetes mellitusLi ZWang FJia YGuo FChen SDove Medical Pressarticlehemoglobin glycation variation indexvitamin dtype 2 diabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1937-1948 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hemoglobin glycation variation index vitamin d type 2 diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	hemoglobin glycation variation index vitamin d type 2 diabetes mellitus Specialties of internal medicine RC581-951 Li Z Wang F Jia Y Guo F Chen S The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus
description	Zelin Li,1,2 Fei Wang,1,2 Yujiao Jia,1,2 Feiyue Guo,1,3 Shuchun Chen1,2,4 1Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Glandular Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 4Hebei Key Laboratory of Metabolic Diseases, Hebei, People’s Republic of ChinaCorrespondence: Shuchun ChenDepartment of Endocrinology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaTel +86 31185988406Fax +86 31185988406Email chenshuc2014@163.comObjective: This study aimed to investigate the relationship between hemoglobin glycation variation index (HGI) and vitamin D in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: This is a cross-sectional study that recruited 347 patients with T2DM. The subjects were divided into no vitamin D deficiency group (25(OH)D ≥ 20 ng/mL) and vitamin D deficiency group (25(OH)D < 20 ng/mL). HGI was calculated as the difference between the measured and predicted values of HbA1c using the linear relationship between HbA1c level and fasting plasma glucose levels. All study participants were divided into high HGI and low HGI groups using the median of HGI as the boundary. At last, the subjects were divided into male group and female group, and these groups were further subdivided into vitamin D deficiency group and no vitamin D deficiency group.Results: The levels of HGI were significantly higher in the vitamin D deficiency group compared with the no vitamin D deficiency group for all patients. The same was true for female patients but not for male patients. The prevalence of vitamin D deficiency in the high HGI group was higher than that in the low HGI group. The high HGI group had lower vitamin D levels compared to the low HGI group. Compared to the male group, the female group had lower vitamin D levels but higher HGI levels. A negative correlation existed between 25(OH) D and HGI in all subjects, as well as in the female-only subgroups. In the male-only subgroups, there was no correlation between them, and this positive correlation still existed after adjusting for other factors in multilinear regression analysis.Conclusion: Our study showed for the first time that HGI is inversely associated with vitamin D in all patients with T2DM, and the correlation was also found in female patients, but not in male patients.Keywords: hemoglobin glycation variation index, vitamin D, type 2 diabetes mellitus
format	article
author	Li Z Wang F Jia Y Guo F Chen S
author_facet	Li Z Wang F Jia Y Guo F Chen S
author_sort	Li Z
title	The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus
title_short	The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus
title_full	The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus
title_fullStr	The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus
title_full_unstemmed	The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus
title_sort	relationship between hemoglobin glycation variation index and vitamin d in type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d84f2e9960ab4e78b913668b711ca7dc
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The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

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