High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer

This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yun-Qian Cui, Fei Meng, Wen-Li Zhan, Zhou-Tong Dai, Xinghua Liao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/d8512a3f81a7484b888fa6993d410dc1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d8512a3f81a7484b888fa6993d410dc1
record_format	dspace
spelling	oai:doaj.org-article:d8512a3f81a7484b888fa6993d410dc12021-11-15T01:19:45ZHigh Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer2314-614110.1155/2021/5282894https://doaj.org/article/d8512a3f81a7484b888fa6993d410dc12021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5282894https://doaj.org/toc/2314-6141This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment.Yun-Qian CuiFei MengWen-Li ZhanZhou-Tong DaiXinghua LiaoHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Yun-Qian Cui Fei Meng Wen-Li Zhan Zhou-Tong Dai Xinghua Liao High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
description	This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment.
format	article
author	Yun-Qian Cui Fei Meng Wen-Li Zhan Zhou-Tong Dai Xinghua Liao
author_facet	Yun-Qian Cui Fei Meng Wen-Li Zhan Zhou-Tong Dai Xinghua Liao
author_sort	Yun-Qian Cui
title	High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_short	High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_full	High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_fullStr	High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_full_unstemmed	High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
title_sort	high expression of gsdmc is associated with poor survival in kidney clear cell cancer
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d8512a3f81a7484b888fa6993d410dc1
work_keys_str_mv	AT yunqiancui highexpressionofgsdmcisassociatedwithpoorsurvivalinkidneyclearcellcancer AT feimeng highexpressionofgsdmcisassociatedwithpoorsurvivalinkidneyclearcellcancer AT wenlizhan highexpressionofgsdmcisassociatedwithpoorsurvivalinkidneyclearcellcancer AT zhoutongdai highexpressionofgsdmcisassociatedwithpoorsurvivalinkidneyclearcellcancer AT xinghualiao highexpressionofgsdmcisassociatedwithpoorsurvivalinkidneyclearcellcancer
_version_	1718428952132845568

High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer

Ejemplares similares