Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Abstract The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study present...

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Autores principales:	Yueying Zhou, Xiaonan Xin, Lichao Wang, Binsheng Wang, Li Chen, Ousheng Liu, David W. Rowe, Ming Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/d85585d8cbab4ac3bee8a3ae54a2b293
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spelling	oai:doaj.org-article:d85585d8cbab4ac3bee8a3ae54a2b2932021-12-02T17:34:47ZSenolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice10.1038/s41536-021-00145-z2057-3995https://doaj.org/article/d85585d8cbab4ac3bee8a3ae54a2b2932021-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00145-zhttps://doaj.org/toc/2057-3995Abstract The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.Yueying ZhouXiaonan XinLichao WangBinsheng WangLi ChenOusheng LiuDavid W. RoweMing XuNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Yueying Zhou Xiaonan Xin Lichao Wang Binsheng Wang Li Chen Ousheng Liu David W. Rowe Ming Xu Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
description	Abstract The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.
format	article
author	Yueying Zhou Xiaonan Xin Lichao Wang Binsheng Wang Li Chen Ousheng Liu David W. Rowe Ming Xu
author_facet	Yueying Zhou Xiaonan Xin Lichao Wang Binsheng Wang Li Chen Ousheng Liu David W. Rowe Ming Xu
author_sort	Yueying Zhou
title	Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_short	Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_full	Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_fullStr	Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_full_unstemmed	Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_sort	senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d85585d8cbab4ac3bee8a3ae54a2b293
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Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

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