Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

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Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Abstract The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study present...

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Auteurs principaux:	Yueying Zhou, Xiaonan Xin, Lichao Wang, Binsheng Wang, Li Chen, Ousheng Liu, David W. Rowe, Ming Xu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Medicine R
Accès en ligne:	https://doaj.org/article/d85585d8cbab4ac3bee8a3ae54a2b293
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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