Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Abstract The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study present...

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Autores principales: Yueying Zhou, Xiaonan Xin, Lichao Wang, Binsheng Wang, Li Chen, Ousheng Liu, David W. Rowe, Ming Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Acceso en línea:https://doaj.org/article/d85585d8cbab4ac3bee8a3ae54a2b293
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