The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and f...

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Autores principales: Maik Luu, Sabine Pautz, Vanessa Kohl, Rajeev Singh, Rossana Romero, Sébastien Lucas, Jörg Hofmann, Hartmann Raifer, Niyati Vachharajani, Lucia Campos Carrascosa, Boris Lamp, Andrea Nist, Thorsten Stiewe, Yoav Shaul, Till Adhikary, Mario M. Zaiss, Matthias Lauth, Ulrich Steinhoff, Alexander Visekruna
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d856e522710041fdbeadd9b5689c49a8
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spelling oai:doaj.org-article:d856e522710041fdbeadd9b5689c49a82021-12-02T17:02:11ZThe short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes10.1038/s41467-019-08711-22041-1723https://doaj.org/article/d856e522710041fdbeadd9b5689c49a82019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08711-2https://doaj.org/toc/2041-1723Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.Maik LuuSabine PautzVanessa KohlRajeev SinghRossana RomeroSébastien LucasJörg HofmannHartmann RaiferNiyati VachharajaniLucia Campos CarrascosaBoris LampAndrea NistThorsten StieweYoav ShaulTill AdhikaryMario M. ZaissMatthias LauthUlrich SteinhoffAlexander VisekrunaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maik Luu
Sabine Pautz
Vanessa Kohl
Rajeev Singh
Rossana Romero
Sébastien Lucas
Jörg Hofmann
Hartmann Raifer
Niyati Vachharajani
Lucia Campos Carrascosa
Boris Lamp
Andrea Nist
Thorsten Stiewe
Yoav Shaul
Till Adhikary
Mario M. Zaiss
Matthias Lauth
Ulrich Steinhoff
Alexander Visekruna
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
description Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.
format article
author Maik Luu
Sabine Pautz
Vanessa Kohl
Rajeev Singh
Rossana Romero
Sébastien Lucas
Jörg Hofmann
Hartmann Raifer
Niyati Vachharajani
Lucia Campos Carrascosa
Boris Lamp
Andrea Nist
Thorsten Stiewe
Yoav Shaul
Till Adhikary
Mario M. Zaiss
Matthias Lauth
Ulrich Steinhoff
Alexander Visekruna
author_facet Maik Luu
Sabine Pautz
Vanessa Kohl
Rajeev Singh
Rossana Romero
Sébastien Lucas
Jörg Hofmann
Hartmann Raifer
Niyati Vachharajani
Lucia Campos Carrascosa
Boris Lamp
Andrea Nist
Thorsten Stiewe
Yoav Shaul
Till Adhikary
Mario M. Zaiss
Matthias Lauth
Ulrich Steinhoff
Alexander Visekruna
author_sort Maik Luu
title The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
title_short The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
title_full The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
title_fullStr The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
title_full_unstemmed The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
title_sort short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d856e522710041fdbeadd9b5689c49a8
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