Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.

Invasive Staphylococcus aureus infections are frequently associated with bacteraemia. To support clinical decisions on antibiotic therapy, there is an urgent need for reliable markers as predictors of infection outcome. In the present study in mice, bacteraemia was established by intravenous inocula...

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Autores principales:	Sanne van den Berg, Jon D Laman, Louis Boon, Marian T ten Kate, Gerjo J de Knegt, Rob M Verdijk, Henri A Verbrugh, Jan L Nouwen, Irma A J M Bakker-Woudenberg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d856f26d911441918b09f192af89f046
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spelling	oai:doaj.org-article:d856f26d911441918b09f192af89f0462021-11-18T07:54:06ZDistinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.1932-620310.1371/journal.pone.0059107https://doaj.org/article/d856f26d911441918b09f192af89f0462013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23520553/?tool=EBIhttps://doaj.org/toc/1932-6203Invasive Staphylococcus aureus infections are frequently associated with bacteraemia. To support clinical decisions on antibiotic therapy, there is an urgent need for reliable markers as predictors of infection outcome. In the present study in mice, bacteraemia was established by intravenous inoculation of a clinical S. aureus isolate at the LD50 inoculum. As potential biomarkers for fatal outcome, blood culture (qualitative and quantitative), serum levels of C-reactive protein (CRP), as well as 31 selected cytokines and chemokines were assessed during the first three days of infection. A positive S. aureus blood culture, the quantitative blood culture, CRP levels, and levels of eight cytokines were indicative for the presence of S. aureus bacteraemia. However, only tumor necrosis factor (TNF) α, interleukin (IL) 1α, and keratinocyte chemoattractant (KC; a functional homologue of human IL-8) were each significantly elevated in eventually non-surviving infected mice versus eventually surviving infected mice. In severe S. aureus bacteraemia in mice, TNF-α, IL-1α, and KC are biomarkers predicting fatal outcome of infection. KC was a biomarker elevated irrespective the progression of infection, which is very interesting regarding clinical application in view of the heterogeneity of patients experiencing bacteraemia in this respect.Sanne van den BergJon D LamanLouis BoonMarian T ten KateGerjo J de KnegtRob M VerdijkHenri A VerbrughJan L NouwenIrma A J M Bakker-WoudenbergPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59107 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanne van den Berg Jon D Laman Louis Boon Marian T ten Kate Gerjo J de Knegt Rob M Verdijk Henri A Verbrugh Jan L Nouwen Irma A J M Bakker-Woudenberg Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.
description	Invasive Staphylococcus aureus infections are frequently associated with bacteraemia. To support clinical decisions on antibiotic therapy, there is an urgent need for reliable markers as predictors of infection outcome. In the present study in mice, bacteraemia was established by intravenous inoculation of a clinical S. aureus isolate at the LD50 inoculum. As potential biomarkers for fatal outcome, blood culture (qualitative and quantitative), serum levels of C-reactive protein (CRP), as well as 31 selected cytokines and chemokines were assessed during the first three days of infection. A positive S. aureus blood culture, the quantitative blood culture, CRP levels, and levels of eight cytokines were indicative for the presence of S. aureus bacteraemia. However, only tumor necrosis factor (TNF) α, interleukin (IL) 1α, and keratinocyte chemoattractant (KC; a functional homologue of human IL-8) were each significantly elevated in eventually non-surviving infected mice versus eventually surviving infected mice. In severe S. aureus bacteraemia in mice, TNF-α, IL-1α, and KC are biomarkers predicting fatal outcome of infection. KC was a biomarker elevated irrespective the progression of infection, which is very interesting regarding clinical application in view of the heterogeneity of patients experiencing bacteraemia in this respect.
format	article
author	Sanne van den Berg Jon D Laman Louis Boon Marian T ten Kate Gerjo J de Knegt Rob M Verdijk Henri A Verbrugh Jan L Nouwen Irma A J M Bakker-Woudenberg
author_facet	Sanne van den Berg Jon D Laman Louis Boon Marian T ten Kate Gerjo J de Knegt Rob M Verdijk Henri A Verbrugh Jan L Nouwen Irma A J M Bakker-Woudenberg
author_sort	Sanne van den Berg
title	Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.
title_short	Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.
title_full	Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.
title_fullStr	Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.
title_full_unstemmed	Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.
title_sort	distinctive cytokines as biomarkers predicting fatal outcome of severe staphylococcus aureus bacteremia in mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d856f26d911441918b09f192af89f046
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Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.

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