Besides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans

Lydia Lera,1,2 Bárbara Angel,1 Carlos Marquez,1 Rodrigo Saguez,1 Cecilia Albala1 1Public Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile; 2Latin Division, Keiser University eCampus, Fort Lauderdale, FL, USACorrespondence: Cecilia Alb...

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Autores principales:	Lera L, Angel B, Marquez C, Saguez R, Albala C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cohort study survival probability predictive models skeletal muscle mass Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d8586657eacf4b04917f2a2191d4a860
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spelling	oai:doaj.org-article:d8586657eacf4b04917f2a2191d4a8602021-12-02T14:39:09ZBesides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans1178-1998https://doaj.org/article/d8586657eacf4b04917f2a2191d4a8602021-04-01T00:00:00Zhttps://www.dovepress.com/besides-sarcopenia-pre-sarcopenia-also-predicts-all-cause-mortality-in-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Lydia Lera,1,2 Bárbara Angel,1 Carlos Marquez,1 Rodrigo Saguez,1 Cecilia Albala1 1Public Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile; 2Latin Division, Keiser University eCampus, Fort Lauderdale, FL, USACorrespondence: Cecilia Albala; Lydia LeraPublic Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, El Líbano 5524, Santiago, 7830490, ChileTel +56229781455; Tel +56 229781537Email calbala@uchile.cl; llera@inta.uchile.clPurpose: Many studies have demonstrated that Sarcopenia causes a serious impact on health, including death in older adults. The objective of this study was to determine the association of sarcopenia and pre-sarcopenia with all-cause mortality in older Chileans.Subjects and Methods: Follow-up of 2311 community-dwelling people ≥ 60y from the Alexandros cohort. Anthropometric measurements, handgrip strength, mobility, and physical performance tests were performed. Sarcopenia, pre-sarcopenia, and severe sarcopenia were defined using the 2010 European Working Group on Sarcopenia in Older People (EWGSOP1) algorithm. Muscle mass was estimated using a prediction model with cut-off points validated for the Chilean population. Physical performance was determined by 3 m walking speed or five chair-stands or time up go test (TUG). Mortality data were obtained from death certificates of the National Civil Registry. Life tables for survival data, Kaplan Meier estimations, and Cox regression were calculated.Results: The prevalence of sarcopenia was 20.2% (95% CI:18.6% to 21.9%) and similar in both sexes; pre-sarcopenia was identified in 20.4% (95% CI:18.8% to 22.1%) of the sample. Kaplan Meier survival estimates demonstrated lower survival rates for the people with sarcopenia and pre-sarcopenia (Log rank test for equality of survivor functions: p< 0.0001). A dose-response was observed in the survival rates according to the stages of sarcopenia, showing the lowest survival rates for the people with severe sarcopenia, followed by older adults with sarcopenia, pre-sarcopenia, and without sarcopenia (Log rank test for equality of survivor functions: p< 0.0001). After adjusting for age, sex, nutritional status, and number of chronic diseases, hazard ratios for death showed higher risk for subjects with sarcopenia (HR=1.47, 95% CI:1.17– 1.83) and pre-sarcopenia (HR=1.35, 95% CI:1.03– 1.78) in comparison with people without sarcopenia.Conclusion: The results confirm a dose–response increase in the risk of all-cause death in older adults with sarcopenia and pre-sarcopenia compared to non-sarcopenic individuals.Keywords: cohort study, survival probability, predictive models, skeletal muscle massLera LAngel BMarquez CSaguez RAlbala CDove Medical Pressarticlecohort studysurvival probabilitypredictive modelsskeletal muscle massGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 611-619 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cohort study survival probability predictive models skeletal muscle mass Geriatrics RC952-954.6
spellingShingle	cohort study survival probability predictive models skeletal muscle mass Geriatrics RC952-954.6 Lera L Angel B Marquez C Saguez R Albala C Besides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans
description	Lydia Lera,1,2 Bárbara Angel,1 Carlos Marquez,1 Rodrigo Saguez,1 Cecilia Albala1 1Public Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile; 2Latin Division, Keiser University eCampus, Fort Lauderdale, FL, USACorrespondence: Cecilia Albala; Lydia LeraPublic Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, El Líbano 5524, Santiago, 7830490, ChileTel +56229781455; Tel +56 229781537Email calbala@uchile.cl; llera@inta.uchile.clPurpose: Many studies have demonstrated that Sarcopenia causes a serious impact on health, including death in older adults. The objective of this study was to determine the association of sarcopenia and pre-sarcopenia with all-cause mortality in older Chileans.Subjects and Methods: Follow-up of 2311 community-dwelling people ≥ 60y from the Alexandros cohort. Anthropometric measurements, handgrip strength, mobility, and physical performance tests were performed. Sarcopenia, pre-sarcopenia, and severe sarcopenia were defined using the 2010 European Working Group on Sarcopenia in Older People (EWGSOP1) algorithm. Muscle mass was estimated using a prediction model with cut-off points validated for the Chilean population. Physical performance was determined by 3 m walking speed or five chair-stands or time up go test (TUG). Mortality data were obtained from death certificates of the National Civil Registry. Life tables for survival data, Kaplan Meier estimations, and Cox regression were calculated.Results: The prevalence of sarcopenia was 20.2% (95% CI:18.6% to 21.9%) and similar in both sexes; pre-sarcopenia was identified in 20.4% (95% CI:18.8% to 22.1%) of the sample. Kaplan Meier survival estimates demonstrated lower survival rates for the people with sarcopenia and pre-sarcopenia (Log rank test for equality of survivor functions: p< 0.0001). A dose-response was observed in the survival rates according to the stages of sarcopenia, showing the lowest survival rates for the people with severe sarcopenia, followed by older adults with sarcopenia, pre-sarcopenia, and without sarcopenia (Log rank test for equality of survivor functions: p< 0.0001). After adjusting for age, sex, nutritional status, and number of chronic diseases, hazard ratios for death showed higher risk for subjects with sarcopenia (HR=1.47, 95% CI:1.17– 1.83) and pre-sarcopenia (HR=1.35, 95% CI:1.03– 1.78) in comparison with people without sarcopenia.Conclusion: The results confirm a dose–response increase in the risk of all-cause death in older adults with sarcopenia and pre-sarcopenia compared to non-sarcopenic individuals.Keywords: cohort study, survival probability, predictive models, skeletal muscle mass
format	article
author	Lera L Angel B Marquez C Saguez R Albala C
author_facet	Lera L Angel B Marquez C Saguez R Albala C
author_sort	Lera L
title	Besides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans
title_short	Besides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans
title_full	Besides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans
title_fullStr	Besides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans
title_full_unstemmed	Besides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans
title_sort	besides sarcopenia, pre-sarcopenia also predicts all-cause mortality in older chileans
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d8586657eacf4b04917f2a2191d4a860
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Besides Sarcopenia, Pre-Sarcopenia Also Predicts All-Cause Mortality in Older Chileans

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