Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness

Harry D Samaroo, Jing Lu, Thomas J WebsterDivision of Engineering, Brown, University, Providence, RI, USAAbstract: The shape memory effect and superelastic properties of NiTi (or Nitinol, a nickel-titanium alloy) have already attracted much attention for various biomedical applications (such as vasc...

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Autores principales:	Harry D Samaroo, Jing Lu, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d858dd21598f4cb192b4805d015f20ca
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spelling	oai:doaj.org-article:d858dd21598f4cb192b4805d015f20ca2021-12-02T01:32:48ZEnhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness1176-91141178-2013https://doaj.org/article/d858dd21598f4cb192b4805d015f20ca2008-03-01T00:00:00Zhttp://www.dovepress.com/enhanced-endothelial-cell-density-on-niti-surfaces-with-sub-micron-to--a739https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Harry D Samaroo, Jing Lu, Thomas J WebsterDivision of Engineering, Brown, University, Providence, RI, USAAbstract: The shape memory effect and superelastic properties of NiTi (or Nitinol, a nickel-titanium alloy) have already attracted much attention for various biomedical applications (such as vascular stents, orthodontic wires, orthopedic implants, etc). However, for vascular stents, conventional approaches have required coating NiTi with anti-thrombogenic or antiinflammatory drug-eluting polymers which as of late have proven problematic for healing atherosclerotic blood vessels. Instead of focusing on the use of drug-eluting anti-thrombogenic or anti-inflammatory proteins, this study focused on promoting the formation of a natural anti-thrombogenic and anti-inflammatory surface on metallic stents: the endothelium. In this study, we synthesized various NiTi substrates with different micron to nanometer surface roughness by using dissimilar dimensions of constituent NiTi powder. Endothelial cell adhesion on these compacts was compared with conventional commercially pure (cp) titanium (Ti) samples. The results after 5 hrs showed that endothelial cells adhered much better on fine grain (&lt;60 &micro;m) compared with coarse grain NiTi compacts (&lt;100 &micro;m). Coarse grain NiTi compacts and conventional Ti promoted similar levels of endothelial cell adhesion. In addition, cells proliferated more after 5 days on NiTi with greater sub-micron and nanoscale surface roughness compared with coarse grain NiTi. In this manner, this study emphasized the positive pole that NiTi with sub-micron to nanometer surface features can play in promoting a natural anti-thrombogenic and anti-inflammatory surface (the endothelium) on a vascular stent and, thus, suggests that more studies should be conducted on NiTi with sub-micron to nanometer surface features. Keywords: nitinol, stents, nanophase, surface roughness, adhesion, endothelial cells Harry D SamarooJing LuThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 1, Pp 75-82 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Harry D Samaroo Jing Lu Thomas J Webster Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
description	Harry D Samaroo, Jing Lu, Thomas J WebsterDivision of Engineering, Brown, University, Providence, RI, USAAbstract: The shape memory effect and superelastic properties of NiTi (or Nitinol, a nickel-titanium alloy) have already attracted much attention for various biomedical applications (such as vascular stents, orthodontic wires, orthopedic implants, etc). However, for vascular stents, conventional approaches have required coating NiTi with anti-thrombogenic or antiinflammatory drug-eluting polymers which as of late have proven problematic for healing atherosclerotic blood vessels. Instead of focusing on the use of drug-eluting anti-thrombogenic or anti-inflammatory proteins, this study focused on promoting the formation of a natural anti-thrombogenic and anti-inflammatory surface on metallic stents: the endothelium. In this study, we synthesized various NiTi substrates with different micron to nanometer surface roughness by using dissimilar dimensions of constituent NiTi powder. Endothelial cell adhesion on these compacts was compared with conventional commercially pure (cp) titanium (Ti) samples. The results after 5 hrs showed that endothelial cells adhered much better on fine grain (&lt;60 &micro;m) compared with coarse grain NiTi compacts (&lt;100 &micro;m). Coarse grain NiTi compacts and conventional Ti promoted similar levels of endothelial cell adhesion. In addition, cells proliferated more after 5 days on NiTi with greater sub-micron and nanoscale surface roughness compared with coarse grain NiTi. In this manner, this study emphasized the positive pole that NiTi with sub-micron to nanometer surface features can play in promoting a natural anti-thrombogenic and anti-inflammatory surface (the endothelium) on a vascular stent and, thus, suggests that more studies should be conducted on NiTi with sub-micron to nanometer surface features. Keywords: nitinol, stents, nanophase, surface roughness, adhesion, endothelial cells
format	article
author	Harry D Samaroo Jing Lu Thomas J Webster
author_facet	Harry D Samaroo Jing Lu Thomas J Webster
author_sort	Harry D Samaroo
title	Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
title_short	Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
title_full	Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
title_fullStr	Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
title_full_unstemmed	Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
title_sort	enhanced endothelial cell density on niti surfaces with sub-micron to nanometer roughness
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/d858dd21598f4cb192b4805d015f20ca
work_keys_str_mv	AT harrydsamaroo enhancedendothelialcelldensityonnitisurfaceswithsubmicrontonanometerroughness AT jinglu enhancedendothelialcelldensityonnitisurfaceswithsubmicrontonanometerroughness AT thomasjwebster enhancedendothelialcelldensityonnitisurfaceswithsubmicrontonanometerroughness
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Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness

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