Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies

Abstract To evaluate the implication of 18F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB patients and 49 controls underwent neuropsychological evaluation and FDG-, DAT-, a...

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Autores principales:	Sung Woo Kang, Seun Jeon, Young-gun Lee, Mincheol Park, Kyoungwon Baik, Jin Ho Jung, Seok Jong Chung, Han Soo Yoo, Seong Ho Jeong, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Alan C. Evans, Byoung Seok Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d859e3fa67fa4c81b8289892302308b3
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spelling	oai:doaj.org-article:d859e3fa67fa4c81b8289892302308b32021-12-02T18:30:57ZImplication of metabolic and dopamine transporter PET in dementia with Lewy bodies10.1038/s41598-021-93442-y2045-2322https://doaj.org/article/d859e3fa67fa4c81b8289892302308b32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93442-yhttps://doaj.org/toc/2045-2322Abstract To evaluate the implication of 18F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB patients and 49 controls underwent neuropsychological evaluation and FDG-, DAT-, and 18F-Florbetaben (FBB) PET. DAT- and FDG-uptake and FDG/DAT ratio were measured in the anterior and posterior striatum. The first principal component (PC1) of FDG subject residual profiles was identified for each subject. Receiver operating characteristic curve analyses for the diagnosis of DLB were performed using FDG- and DAT-PET biomarkers as predictors, and general linear models for motor severity and cognitive scores were performed adding FBB standardized uptake value ratio as a predictor. Increased metabolism in the bilateral putamen, vermis, and somato-motor cortices, which characterized PC1, was observed in the DLB group, compared to the control group. A combination of posterior putamen FDG/DAT ratio and PC1 showed the highest diagnostic accuracy (91.8% sensitivity and 96.4% specificity), which was significantly greater than that obtained by DAT uptake alone. Striatal DAT uptake and PC1 independently contributed to motor severity and language, memory, frontal/executive, and general cognitive dysfunction in DLB patients, while only PC1 contributed to attention and visuospatial dysfunction.Sung Woo KangSeun JeonYoung-gun LeeMincheol ParkKyoungwon BaikJin Ho JungSeok Jong ChungHan Soo YooSeong Ho JeongMijin YunPhil Hyu LeeYoung H. SohnAlan C. EvansByoung Seok YeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sung Woo Kang Seun Jeon Young-gun Lee Mincheol Park Kyoungwon Baik Jin Ho Jung Seok Jong Chung Han Soo Yoo Seong Ho Jeong Mijin Yun Phil Hyu Lee Young H. Sohn Alan C. Evans Byoung Seok Ye Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies
description	Abstract To evaluate the implication of 18F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB patients and 49 controls underwent neuropsychological evaluation and FDG-, DAT-, and 18F-Florbetaben (FBB) PET. DAT- and FDG-uptake and FDG/DAT ratio were measured in the anterior and posterior striatum. The first principal component (PC1) of FDG subject residual profiles was identified for each subject. Receiver operating characteristic curve analyses for the diagnosis of DLB were performed using FDG- and DAT-PET biomarkers as predictors, and general linear models for motor severity and cognitive scores were performed adding FBB standardized uptake value ratio as a predictor. Increased metabolism in the bilateral putamen, vermis, and somato-motor cortices, which characterized PC1, was observed in the DLB group, compared to the control group. A combination of posterior putamen FDG/DAT ratio and PC1 showed the highest diagnostic accuracy (91.8% sensitivity and 96.4% specificity), which was significantly greater than that obtained by DAT uptake alone. Striatal DAT uptake and PC1 independently contributed to motor severity and language, memory, frontal/executive, and general cognitive dysfunction in DLB patients, while only PC1 contributed to attention and visuospatial dysfunction.
format	article
author	Sung Woo Kang Seun Jeon Young-gun Lee Mincheol Park Kyoungwon Baik Jin Ho Jung Seok Jong Chung Han Soo Yoo Seong Ho Jeong Mijin Yun Phil Hyu Lee Young H. Sohn Alan C. Evans Byoung Seok Ye
author_facet	Sung Woo Kang Seun Jeon Young-gun Lee Mincheol Park Kyoungwon Baik Jin Ho Jung Seok Jong Chung Han Soo Yoo Seong Ho Jeong Mijin Yun Phil Hyu Lee Young H. Sohn Alan C. Evans Byoung Seok Ye
author_sort	Sung Woo Kang
title	Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies
title_short	Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies
title_full	Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies
title_fullStr	Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies
title_full_unstemmed	Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies
title_sort	implication of metabolic and dopamine transporter pet in dementia with lewy bodies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d859e3fa67fa4c81b8289892302308b3
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Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies

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