Randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate

Jaime Pablo Kelly Rigollet, Joan Anton Ondategui, Angels Pasto, Laura Lop, Institut Catal&agrave; de la Salut, Centre de Atenci&oacute; Prim&agrave;ria MANSO, Eixample esquerra, Barcelona, Spain, The results of this were first presented in the World Glaucoma Congress, Boston...

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Autores principales:	Jaime Pablo Kelly Rigollet, Joan Anton Ondategui, Angels Pasto, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d85bbc77495a41fdba4d199e6b9736c1
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spelling	oai:doaj.org-article:d85bbc77495a41fdba4d199e6b9736c12021-12-02T05:49:49ZRandomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate1177-54671177-5483https://doaj.org/article/d85bbc77495a41fdba4d199e6b9736c12011-02-01T00:00:00Zhttp://www.dovepress.com/randomized-trial-comparing-three-fixed-combinations-of-prostaglandinsp-a6281https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Jaime Pablo Kelly Rigollet, Joan Anton Ondategui, Angels Pasto, Laura Lop, Institut Catal&agrave; de la Salut, Centre de Atenci&oacute; Prim&agrave;ria MANSO, Eixample esquerra, Barcelona, Spain, The results of this were first presented in the World Glaucoma Congress, Boston (8&ndash;11 July 2009)Introduction: To evaluate the long-term efficacy and safety of 3 commercially available fixed combinations of prostaglandin analogs or a prostamide with timolol maleate in patients with primary open angle glaucoma or ocular hypertension.Methods: In this randomized, prospective, single-blind study, intraocular pressure (IOP) was measured after a 1-month washout period and pachymetry was performed before randomizing patients to latanoprost 50 &micro;g/timolol 5 mg/1 mL (L/T), bimatoprost 300 &micro;g/timolol 5 mg/1 mL (B/T), or travoprost 40 &micro;g/timolol 5 mg/1 mL (T/T). IOP was measured monthly for 6 months and then at 12 months by an investigator blinded to the study drug. Adverse reactions were recorded.Results: 128 cases were included in the study. The 3 treatment groups had similar baseline characteristics and comparable IOP. All 3 combinations decreased IOP by at least 6 mmHg and IOP remained below 21 mmHg throughout the study. At 12 months L/T achieved greater reduction in IOP than the other 2 fixed combinations, but the difference between L/T and B/T was not statistically significant. At 6 months, more B/T-treated patients reported red eye (P &lt; 0.05 vs L/T and T/T). At 12 months, fewer adverse reactions were reported, with no cases of red eye reported for L/T (P = 0.03 vs B/T).Conclusions: All 3 combinations are effective at lowering IOP but at 12 months L/T and B/T were found to be more effective than T/T. Treatments were well tolerated after 12 months but L/T showed less hyperemia than B/T throughout the study (P &lt; 0.05).Keywords: bimatoprost/timolol, fixed combinations, intraocular pressure, latanoprost/timolol, ocular hypertension, primary open angle glaucoma, travoprost/timolol. Jaime Pablo Kelly RigolletJoan Anton OndateguiAngels Pastoet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 187-191 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Jaime Pablo Kelly Rigollet Joan Anton Ondategui Angels Pasto et al Randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate
description	Jaime Pablo Kelly Rigollet, Joan Anton Ondategui, Angels Pasto, Laura Lop, Institut Catal&agrave; de la Salut, Centre de Atenci&oacute; Prim&agrave;ria MANSO, Eixample esquerra, Barcelona, Spain, The results of this were first presented in the World Glaucoma Congress, Boston (8&ndash;11 July 2009)Introduction: To evaluate the long-term efficacy and safety of 3 commercially available fixed combinations of prostaglandin analogs or a prostamide with timolol maleate in patients with primary open angle glaucoma or ocular hypertension.Methods: In this randomized, prospective, single-blind study, intraocular pressure (IOP) was measured after a 1-month washout period and pachymetry was performed before randomizing patients to latanoprost 50 &micro;g/timolol 5 mg/1 mL (L/T), bimatoprost 300 &micro;g/timolol 5 mg/1 mL (B/T), or travoprost 40 &micro;g/timolol 5 mg/1 mL (T/T). IOP was measured monthly for 6 months and then at 12 months by an investigator blinded to the study drug. Adverse reactions were recorded.Results: 128 cases were included in the study. The 3 treatment groups had similar baseline characteristics and comparable IOP. All 3 combinations decreased IOP by at least 6 mmHg and IOP remained below 21 mmHg throughout the study. At 12 months L/T achieved greater reduction in IOP than the other 2 fixed combinations, but the difference between L/T and B/T was not statistically significant. At 6 months, more B/T-treated patients reported red eye (P &lt; 0.05 vs L/T and T/T). At 12 months, fewer adverse reactions were reported, with no cases of red eye reported for L/T (P = 0.03 vs B/T).Conclusions: All 3 combinations are effective at lowering IOP but at 12 months L/T and B/T were found to be more effective than T/T. Treatments were well tolerated after 12 months but L/T showed less hyperemia than B/T throughout the study (P &lt; 0.05).Keywords: bimatoprost/timolol, fixed combinations, intraocular pressure, latanoprost/timolol, ocular hypertension, primary open angle glaucoma, travoprost/timolol.
format	article
author	Jaime Pablo Kelly Rigollet Joan Anton Ondategui Angels Pasto et al
author_facet	Jaime Pablo Kelly Rigollet Joan Anton Ondategui Angels Pasto et al
author_sort	Jaime Pablo Kelly Rigollet
title	Randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate
title_short	Randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate
title_full	Randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate
title_fullStr	Randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate
title_full_unstemmed	Randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate
title_sort	randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/d85bbc77495a41fdba4d199e6b9736c1
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Randomized trial comparing three fixed combinations of prostaglandins/prostamide with timolol maleate

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