Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours

The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, inclu...

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Autores principales:	Nicola Cirillo, Carmen Wu, Stephen S. Prime
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer stem cells head and neck tumours CD44 ALDH CD133 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d85c3d01ef82433197f39313e67c4eb4
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spelling	oai:doaj.org-article:d85c3d01ef82433197f39313e67c4eb42021-11-25T17:11:06ZHeterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours10.3390/cells101130682073-4409https://doaj.org/article/d85c3d01ef82433197f39313e67c4eb42021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3068https://doaj.org/toc/2073-4409The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, distinct HNCSC subsets play different roles in the generation and progression of tumours. This article aims to review the evidence for a role of specific CSCs in HNSCC tumorigenesis, invasion, and metastasis, together with resistance to treatment.Nicola CirilloCarmen WuStephen S. PrimeMDPI AGarticlecancer stem cellshead and neck tumoursCD44ALDHCD133Biology (General)QH301-705.5ENCells, Vol 10, Iss 3068, p 3068 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer stem cells head and neck tumours CD44 ALDH CD133 Biology (General) QH301-705.5
spellingShingle	cancer stem cells head and neck tumours CD44 ALDH CD133 Biology (General) QH301-705.5 Nicola Cirillo Carmen Wu Stephen S. Prime Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
description	The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, distinct HNCSC subsets play different roles in the generation and progression of tumours. This article aims to review the evidence for a role of specific CSCs in HNSCC tumorigenesis, invasion, and metastasis, together with resistance to treatment.
format	article
author	Nicola Cirillo Carmen Wu Stephen S. Prime
author_facet	Nicola Cirillo Carmen Wu Stephen S. Prime
author_sort	Nicola Cirillo
title	Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
title_short	Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
title_full	Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
title_fullStr	Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
title_full_unstemmed	Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
title_sort	heterogeneity of cancer stem cells in tumorigenesis, metastasis, and resistance to antineoplastic treatment of head and neck tumours
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d85c3d01ef82433197f39313e67c4eb4
work_keys_str_mv	AT nicolacirillo heterogeneityofcancerstemcellsintumorigenesismetastasisandresistancetoantineoplastictreatmentofheadandnecktumours AT carmenwu heterogeneityofcancerstemcellsintumorigenesismetastasisandresistancetoantineoplastictreatmentofheadandnecktumours AT stephensprime heterogeneityofcancerstemcellsintumorigenesismetastasisandresistancetoantineoplastictreatmentofheadandnecktumours
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Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours

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