Single cell analysis of kynurenine and System L amino acid transport in T cells

Kynurenine is an immunomodulatory aryl hydrocarbon receptor (AHR) ligand. Here the authors show, using a new flow cytometry based method, that kynurenine needs to be transported across the plasma membrane of activated T cells by the transporter protein SLC7A5 to activate the AHR.

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Autores principales:	Linda V. Sinclair, Damien Neyens, George Ramsay, Peter M. Taylor, Doreen A. Cantrell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d860c1c2a7b44c229d50bae26faa0f86
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spelling	oai:doaj.org-article:d860c1c2a7b44c229d50bae26faa0f862021-12-02T17:32:01ZSingle cell analysis of kynurenine and System L amino acid transport in T cells10.1038/s41467-018-04366-72041-1723https://doaj.org/article/d860c1c2a7b44c229d50bae26faa0f862018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04366-7https://doaj.org/toc/2041-1723Kynurenine is an immunomodulatory aryl hydrocarbon receptor (AHR) ligand. Here the authors show, using a new flow cytometry based method, that kynurenine needs to be transported across the plasma membrane of activated T cells by the transporter protein SLC7A5 to activate the AHR.Linda V. SinclairDamien NeyensGeorge RamsayPeter M. TaylorDoreen A. CantrellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linda V. Sinclair Damien Neyens George Ramsay Peter M. Taylor Doreen A. Cantrell Single cell analysis of kynurenine and System L amino acid transport in T cells
description	Kynurenine is an immunomodulatory aryl hydrocarbon receptor (AHR) ligand. Here the authors show, using a new flow cytometry based method, that kynurenine needs to be transported across the plasma membrane of activated T cells by the transporter protein SLC7A5 to activate the AHR.
format	article
author	Linda V. Sinclair Damien Neyens George Ramsay Peter M. Taylor Doreen A. Cantrell
author_facet	Linda V. Sinclair Damien Neyens George Ramsay Peter M. Taylor Doreen A. Cantrell
author_sort	Linda V. Sinclair
title	Single cell analysis of kynurenine and System L amino acid transport in T cells
title_short	Single cell analysis of kynurenine and System L amino acid transport in T cells
title_full	Single cell analysis of kynurenine and System L amino acid transport in T cells
title_fullStr	Single cell analysis of kynurenine and System L amino acid transport in T cells
title_full_unstemmed	Single cell analysis of kynurenine and System L amino acid transport in T cells
title_sort	single cell analysis of kynurenine and system l amino acid transport in t cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d860c1c2a7b44c229d50bae26faa0f86
work_keys_str_mv	AT lindavsinclair singlecellanalysisofkynurenineandsystemlaminoacidtransportintcells AT damienneyens singlecellanalysisofkynurenineandsystemlaminoacidtransportintcells AT georgeramsay singlecellanalysisofkynurenineandsystemlaminoacidtransportintcells AT petermtaylor singlecellanalysisofkynurenineandsystemlaminoacidtransportintcells AT doreenacantrell singlecellanalysisofkynurenineandsystemlaminoacidtransportintcells
_version_	1718380461365919744

Single cell analysis of kynurenine and System L amino acid transport in T cells

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