Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments

Short cationic peptides and nucleotides can form complex coacervates, but the influence of reduced multivalency on coacervate functionality was not investigated. Here, the authors report that coacervates formed from short polyions generate distinct pH microenvironments, accumulate RNA and preserve n...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatma Pir Cakmak, Saehyun Choi, McCauley O. Meyer, Philip C. Bevilacqua, Christine D. Keating
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d861f2e1aa72455a95349767626d8ff5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d861f2e1aa72455a95349767626d8ff5
record_format	dspace
spelling	oai:doaj.org-article:d861f2e1aa72455a95349767626d8ff52021-12-02T13:57:56ZPrebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments10.1038/s41467-020-19775-w2041-1723https://doaj.org/article/d861f2e1aa72455a95349767626d8ff52020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19775-whttps://doaj.org/toc/2041-1723Short cationic peptides and nucleotides can form complex coacervates, but the influence of reduced multivalency on coacervate functionality was not investigated. Here, the authors report that coacervates formed from short polyions generate distinct pH microenvironments, accumulate RNA and preserve nucleic acid duplexes more efficiently than their longer counterparts.Fatma Pir CakmakSaehyun ChoiMcCauley O. MeyerPhilip C. BevilacquaChristine D. KeatingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fatma Pir Cakmak Saehyun Choi McCauley O. Meyer Philip C. Bevilacqua Christine D. Keating Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments
description	Short cationic peptides and nucleotides can form complex coacervates, but the influence of reduced multivalency on coacervate functionality was not investigated. Here, the authors report that coacervates formed from short polyions generate distinct pH microenvironments, accumulate RNA and preserve nucleic acid duplexes more efficiently than their longer counterparts.
format	article
author	Fatma Pir Cakmak Saehyun Choi McCauley O. Meyer Philip C. Bevilacqua Christine D. Keating
author_facet	Fatma Pir Cakmak Saehyun Choi McCauley O. Meyer Philip C. Bevilacqua Christine D. Keating
author_sort	Fatma Pir Cakmak
title	Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments
title_short	Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments
title_full	Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments
title_fullStr	Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments
title_full_unstemmed	Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments
title_sort	prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d861f2e1aa72455a95349767626d8ff5
work_keys_str_mv	AT fatmapircakmak prebioticallyrelevantlowpolyionmultivalencycanimprovefunctionalityofmembranelesscompartments AT saehyunchoi prebioticallyrelevantlowpolyionmultivalencycanimprovefunctionalityofmembranelesscompartments AT mccauleyomeyer prebioticallyrelevantlowpolyionmultivalencycanimprovefunctionalityofmembranelesscompartments AT philipcbevilacqua prebioticallyrelevantlowpolyionmultivalencycanimprovefunctionalityofmembranelesscompartments AT christinedkeating prebioticallyrelevantlowpolyionmultivalencycanimprovefunctionalityofmembranelesscompartments
_version_	1718392289842167808

Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments

Ejemplares similares