A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer

Alex A Daly,1 Rachel Rolph,2 Ramsey I Cutress,1 Ellen R Copson1 1Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; 2Department of Breast Surgery, Royal Marsden Hospital, London, SW3 6JJ, UKCorrespondence: Ellen R CopsonSomers Cancer Sciences Bu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daly AA, Rolph R, Cutress RI, Copson ER
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	modifiable risk factors lifestyle breast cancer prevention young running header: modifiable risk factors for young onset breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d86273517bba4b7cbcdf264ab01a1704
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d86273517bba4b7cbcdf264ab01a1704
record_format	dspace
spelling	oai:doaj.org-article:d86273517bba4b7cbcdf264ab01a17042021-12-02T14:38:14ZA Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer1179-1314https://doaj.org/article/d86273517bba4b7cbcdf264ab01a17042021-04-01T00:00:00Zhttps://www.dovepress.com/a-review-of-modifiable-risk-factors-in-young-women-for-the-prevention--peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Alex A Daly,1 Rachel Rolph,2 Ramsey I Cutress,1 Ellen R Copson1 1Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; 2Department of Breast Surgery, Royal Marsden Hospital, London, SW3 6JJ, UKCorrespondence: Ellen R CopsonSomers Cancer Sciences Building, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UKTel +44 23 8120 5170Fax +44 23 8120 5152Email E.Copson@soton.ac.ukAbstract: Breast cancer is the most common cancer diagnosis in women aged less than 40 years and the second most common cause of cancer death in this age group. Global rates of young onset breast cancer have risen steadily over the last twenty years. Although young women with breast cancer have a higher frequency of underlying pathogenic mutations in high penetrance breast cancer susceptibility genes (CSG) than older women, the vast majority of young breast cancer patients are not found to have a germline CSG mutation. There is therefore a need to inform young women regarding non-genetic breast cancer risk factors which have the potential to be influenced by changes in individual behaviour. A Pubmed search was performed using the search terms “young” or “early onset”, and “breast cancer” and “modifiable risk”. Titles and abstracts from peer-reviewed publications were screened for relevance. This review presents evidence for potentially modifiable risk factors of breast cancer risk in young women, including lifestyle factors (physical activity, body habitus, alcohol use, smoking, shift work and socioeconomic factors), reproductive and hormonal factors and iatrogenic risks. The extent to which these factors are truly modifiable is discussed and interactions between genetic and non-genetic risk factors are also addressed. Health care professionals have an opportunity to inform young women about breast health and risk when presenting at a “teachable moment”, including the benefits of physical activity and alcohol habits as risk factor. More focussed discussions regarding individual personal risk and benefit should accompany conversations regarding reproductive health and take into consideration both non-modifiable and iatrogenic BC risk factors.Keywords: modifiable, risk factors, lifestyle, breast cancer, prevention, youngDaly AARolph RCutress RICopson ERDove Medical Pressarticlemodifiablerisk factorslifestylebreast cancerpreventionyoung running header: modifiable risk factors for young onset breast cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 13, Pp 241-257 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	modifiable risk factors lifestyle breast cancer prevention young running header: modifiable risk factors for young onset breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	modifiable risk factors lifestyle breast cancer prevention young running header: modifiable risk factors for young onset breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Daly AA Rolph R Cutress RI Copson ER A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer
description	Alex A Daly,1 Rachel Rolph,2 Ramsey I Cutress,1 Ellen R Copson1 1Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; 2Department of Breast Surgery, Royal Marsden Hospital, London, SW3 6JJ, UKCorrespondence: Ellen R CopsonSomers Cancer Sciences Building, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UKTel +44 23 8120 5170Fax +44 23 8120 5152Email E.Copson@soton.ac.ukAbstract: Breast cancer is the most common cancer diagnosis in women aged less than 40 years and the second most common cause of cancer death in this age group. Global rates of young onset breast cancer have risen steadily over the last twenty years. Although young women with breast cancer have a higher frequency of underlying pathogenic mutations in high penetrance breast cancer susceptibility genes (CSG) than older women, the vast majority of young breast cancer patients are not found to have a germline CSG mutation. There is therefore a need to inform young women regarding non-genetic breast cancer risk factors which have the potential to be influenced by changes in individual behaviour. A Pubmed search was performed using the search terms “young” or “early onset”, and “breast cancer” and “modifiable risk”. Titles and abstracts from peer-reviewed publications were screened for relevance. This review presents evidence for potentially modifiable risk factors of breast cancer risk in young women, including lifestyle factors (physical activity, body habitus, alcohol use, smoking, shift work and socioeconomic factors), reproductive and hormonal factors and iatrogenic risks. The extent to which these factors are truly modifiable is discussed and interactions between genetic and non-genetic risk factors are also addressed. Health care professionals have an opportunity to inform young women about breast health and risk when presenting at a “teachable moment”, including the benefits of physical activity and alcohol habits as risk factor. More focussed discussions regarding individual personal risk and benefit should accompany conversations regarding reproductive health and take into consideration both non-modifiable and iatrogenic BC risk factors.Keywords: modifiable, risk factors, lifestyle, breast cancer, prevention, young
format	article
author	Daly AA Rolph R Cutress RI Copson ER
author_facet	Daly AA Rolph R Cutress RI Copson ER
author_sort	Daly AA
title	A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer
title_short	A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer
title_full	A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer
title_fullStr	A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer
title_full_unstemmed	A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer
title_sort	review of modifiable risk factors in young women for the prevention of breast cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d86273517bba4b7cbcdf264ab01a1704
work_keys_str_mv	AT dalyaa areviewofmodifiableriskfactorsinyoungwomenforthepreventionofbreastcancer AT rolphr areviewofmodifiableriskfactorsinyoungwomenforthepreventionofbreastcancer AT cutressri areviewofmodifiableriskfactorsinyoungwomenforthepreventionofbreastcancer AT copsoner areviewofmodifiableriskfactorsinyoungwomenforthepreventionofbreastcancer AT dalyaa reviewofmodifiableriskfactorsinyoungwomenforthepreventionofbreastcancer AT rolphr reviewofmodifiableriskfactorsinyoungwomenforthepreventionofbreastcancer AT cutressri reviewofmodifiableriskfactorsinyoungwomenforthepreventionofbreastcancer AT copsoner reviewofmodifiableriskfactorsinyoungwomenforthepreventionofbreastcancer
_version_	1718390981151162368

A Review of Modifiable Risk Factors in Young Women for the Prevention of Breast Cancer

Ejemplares similares