Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy

Aim. We evaluated the clinical and functional characteristics of gastroesophageal reflux disease (GERD) in adolescents with a cardiac form of diabetic autonomic neuropathy. Patients and methods. Fifty-two adolescents, aged 12?17 years, with type 1 diabetes were studied. Patients were divided into...

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Autores principales:	Sergey Evgen'evich Kostyakov, Irina Leonidovna Alimova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	type 1 diabetes diabetic autonomic neuropathy gastroesophageal reflux Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/d864c74964844664a19f3a31af6fcb60
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spelling	oai:doaj.org-article:d864c74964844664a19f3a31af6fcb602021-11-14T09:00:19ZClinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy2072-03512072-037810.14341/DM2014493-98https://doaj.org/article/d864c74964844664a19f3a31af6fcb602014-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6618https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. We evaluated the clinical and functional characteristics of gastroesophageal reflux disease (GERD) in adolescents with a cardiac form of diabetic autonomic neuropathy. Patients and methods. Fifty-two adolescents, aged 12?17 years, with type 1 diabetes were studied. Patients were divided into two groups according to the results of two autonomic tests (cardiointervalography and Valsalva test). Group 1 included 14 adolescents with a cardiac form of diabetic autonomic neuropathy. Group 2 included 38 controls. Oesophageal pH parameters were monitored over 24 h using a Gastroscan-24. The 24-h period was divided into day-time (08:00?22:00) and night-time (22:00?08:00) periods to eliminate the influence of exogenous factors (such as eating, physical activity and change of body position) on the oesophageal kinetic function. Results. Pathological gastroesophageal reflux occurred more frequently in Group 1 (78.5%) than in Group 2 (36.8%; p=0.018). Heartburn was experienced by 14.3% of the patients in Group 1 and generally occurred with similar frequency in the two groups (p=0.91). The daily amount of pathological acid reflux in Group 1 (86 [62?141]) was higher versus Group 2 (52.5 [24?108]; p=0.047) that was associated with night-time reflux in Group 1. A correlation analysis demonstrated the increase of frequency and intensity of the acid reflux due to development of parasympathetic insufficiency. Conclusion. Diabetic autonomic neuropathy in adolescents with type 1 diabetes appears to be a significant risk factor for the development of pathological subclinical GERD with altered daily pattern.Sergey Evgen'evich KostyakovIrina Leonidovna AlimovaEndocrinology Research Centrearticletype 1 diabetesdiabetic autonomic neuropathygastroesophageal refluxNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 4, Pp 93-98 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes diabetic autonomic neuropathy gastroesophageal reflux Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes diabetic autonomic neuropathy gastroesophageal reflux Nutritional diseases. Deficiency diseases RC620-627 Sergey Evgen'evich Kostyakov Irina Leonidovna Alimova Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy
description	Aim. We evaluated the clinical and functional characteristics of gastroesophageal reflux disease (GERD) in adolescents with a cardiac form of diabetic autonomic neuropathy. Patients and methods. Fifty-two adolescents, aged 12?17 years, with type 1 diabetes were studied. Patients were divided into two groups according to the results of two autonomic tests (cardiointervalography and Valsalva test). Group 1 included 14 adolescents with a cardiac form of diabetic autonomic neuropathy. Group 2 included 38 controls. Oesophageal pH parameters were monitored over 24 h using a Gastroscan-24. The 24-h period was divided into day-time (08:00?22:00) and night-time (22:00?08:00) periods to eliminate the influence of exogenous factors (such as eating, physical activity and change of body position) on the oesophageal kinetic function. Results. Pathological gastroesophageal reflux occurred more frequently in Group 1 (78.5%) than in Group 2 (36.8%; p=0.018). Heartburn was experienced by 14.3% of the patients in Group 1 and generally occurred with similar frequency in the two groups (p=0.91). The daily amount of pathological acid reflux in Group 1 (86 [62?141]) was higher versus Group 2 (52.5 [24?108]; p=0.047) that was associated with night-time reflux in Group 1. A correlation analysis demonstrated the increase of frequency and intensity of the acid reflux due to development of parasympathetic insufficiency. Conclusion. Diabetic autonomic neuropathy in adolescents with type 1 diabetes appears to be a significant risk factor for the development of pathological subclinical GERD with altered daily pattern.
format	article
author	Sergey Evgen'evich Kostyakov Irina Leonidovna Alimova
author_facet	Sergey Evgen'evich Kostyakov Irina Leonidovna Alimova
author_sort	Sergey Evgen'evich Kostyakov
title	Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy
title_short	Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy
title_full	Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy
title_fullStr	Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy
title_full_unstemmed	Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy
title_sort	clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/d864c74964844664a19f3a31af6fcb60
work_keys_str_mv	AT sergeyevgenevichkostyakov clinicalcharacteristicsofgastroesophagealrefluxdiseaseinadolescentswithdiabeticcardiacautonomicneuropathy AT irinaleonidovnaalimova clinicalcharacteristicsofgastroesophagealrefluxdiseaseinadolescentswithdiabeticcardiacautonomicneuropathy
_version_	1718429558406905856

Clinical characteristics of gastroesophageal reflux disease in adolescents with diabetic cardiac autonomic neuropathy

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