Bacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh

Abdulrahman Almizel,1 Fahad A Alsuhaibani,1 Abdulrahman M Alkaff,1 Ahmed S Alsaleh,1 Samir M AL-Mansouri2 1College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Abdulrahman AlmizelCollege of Medicine,...

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Autores principales:	Almizel A, Alsuhaibani FA, Alkaff AM, Alsaleh AS, AL-Mansouri SM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	keratitis antibiotic infection Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d864dfbc7a3e4d45810e065fbc9a4e60
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spelling	oai:doaj.org-article:d864dfbc7a3e4d45810e065fbc9a4e602021-12-02T04:39:26ZBacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh1177-5483https://doaj.org/article/d864dfbc7a3e4d45810e065fbc9a4e602019-12-01T00:00:00Zhttps://www.dovepress.com/bacterial-profile-and-antibiotic-susceptibility-pattern-of-bacterial-k-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Abdulrahman Almizel,1 Fahad A Alsuhaibani,1 Abdulrahman M Alkaff,1 Ahmed S Alsaleh,1 Samir M AL-Mansouri2 1College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Abdulrahman AlmizelCollege of Medicine, King Saud University, Riyadh 11451, Saudi ArabiaEmail Amalmizel@gmail.comBackground: The most common cause of ocular infections worldwide is bacteria; therefore, bacterial keratitis requires rapid and proper intervention because it is a major cause of loss of vision and ocular morbidity. Resistance studies have found increases in the resistance to ciprofloxacin, cefazolin, and gentamicin in bacterial keratitis cases that are caused by gram-positive organisms.Aim: To identify the common predisposing factors, causative organisms, and antibiotic profile of bacterial keratitis (BK) in a tertiary care hospital in Riyadh, Saudi Arabia.Method: This is a retrospective study of the microbiological record of all patients diagnosed with BK at KAUH. From the first of May 2015 until the first of January 2018. Demographic data, diabetes mellitus, contact lens use, history of eye trauma, ocular surface disorders, recent ocular surgeries, current and recent medications, initial and final visual acuity, and location and size of the infiltrate were all used in the study. VA was converted to the logarithm of the minimum angle of resolution (LogMAR) for statistical analysis.Results: 177 cases positive for BK were included. 100 (56.5%) were males, and 77 (43.5%) were females. The mean age was 43.15. Trauma was the most common predisposing factor, which was observed in 68 (38.4%) cases, followed by Ocular surface disease [52 (29.4%)]. Staphylococcus epidermidis was the most commonly isolated organism [61 (34.5%)], followed by Streptococcus pneumoniae [23 (13%)], and Staphylococcus aureus [18 (10.2%)]. All gram-positive cases were Vancomycin sensitive. Staphylococcus epidermidis showed only 4 resistant cases to chloramphenicol (7.27%), and resistance to penicillin and ampicillin was found in 55 (90%) and 53 (89.83%) cases, respectively. All Streptococcus pneumoniae cases were resistant to gentamicin (100%). Staphylococcus aureus showed high sensitivity for erythromycin [18 (100%)].Conclusion: The most common cause of bacterial keratitis was Staphylococcus epidermidis (N=61), followed by Streptococcus pneumoniae (N=23). Trauma was the most common predisposing factor (38.4%), while contact lens use was only identified in 14 cases (7.9%). All organisms tested were sensitive to vancomycin, and there was high resistance toward penicillin (90%).Keywords: keratitis, antibiotic, infectionAlmizel AAlsuhaibani FAAlkaff AMAlsaleh ASAL-Mansouri SMDove Medical PressarticlekeratitisantibioticinfectionOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2547-2552 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	keratitis antibiotic infection Ophthalmology RE1-994
spellingShingle	keratitis antibiotic infection Ophthalmology RE1-994 Almizel A Alsuhaibani FA Alkaff AM Alsaleh AS AL-Mansouri SM Bacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh
description	Abdulrahman Almizel,1 Fahad A Alsuhaibani,1 Abdulrahman M Alkaff,1 Ahmed S Alsaleh,1 Samir M AL-Mansouri2 1College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Abdulrahman AlmizelCollege of Medicine, King Saud University, Riyadh 11451, Saudi ArabiaEmail Amalmizel@gmail.comBackground: The most common cause of ocular infections worldwide is bacteria; therefore, bacterial keratitis requires rapid and proper intervention because it is a major cause of loss of vision and ocular morbidity. Resistance studies have found increases in the resistance to ciprofloxacin, cefazolin, and gentamicin in bacterial keratitis cases that are caused by gram-positive organisms.Aim: To identify the common predisposing factors, causative organisms, and antibiotic profile of bacterial keratitis (BK) in a tertiary care hospital in Riyadh, Saudi Arabia.Method: This is a retrospective study of the microbiological record of all patients diagnosed with BK at KAUH. From the first of May 2015 until the first of January 2018. Demographic data, diabetes mellitus, contact lens use, history of eye trauma, ocular surface disorders, recent ocular surgeries, current and recent medications, initial and final visual acuity, and location and size of the infiltrate were all used in the study. VA was converted to the logarithm of the minimum angle of resolution (LogMAR) for statistical analysis.Results: 177 cases positive for BK were included. 100 (56.5%) were males, and 77 (43.5%) were females. The mean age was 43.15. Trauma was the most common predisposing factor, which was observed in 68 (38.4%) cases, followed by Ocular surface disease [52 (29.4%)]. Staphylococcus epidermidis was the most commonly isolated organism [61 (34.5%)], followed by Streptococcus pneumoniae [23 (13%)], and Staphylococcus aureus [18 (10.2%)]. All gram-positive cases were Vancomycin sensitive. Staphylococcus epidermidis showed only 4 resistant cases to chloramphenicol (7.27%), and resistance to penicillin and ampicillin was found in 55 (90%) and 53 (89.83%) cases, respectively. All Streptococcus pneumoniae cases were resistant to gentamicin (100%). Staphylococcus aureus showed high sensitivity for erythromycin [18 (100%)].Conclusion: The most common cause of bacterial keratitis was Staphylococcus epidermidis (N=61), followed by Streptococcus pneumoniae (N=23). Trauma was the most common predisposing factor (38.4%), while contact lens use was only identified in 14 cases (7.9%). All organisms tested were sensitive to vancomycin, and there was high resistance toward penicillin (90%).Keywords: keratitis, antibiotic, infection
format	article
author	Almizel A Alsuhaibani FA Alkaff AM Alsaleh AS AL-Mansouri SM
author_facet	Almizel A Alsuhaibani FA Alkaff AM Alsaleh AS AL-Mansouri SM
author_sort	Almizel A
title	Bacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh
title_short	Bacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh
title_full	Bacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh
title_fullStr	Bacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh
title_full_unstemmed	Bacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh
title_sort	bacterial profile and antibiotic susceptibility pattern of bacterial keratitis at a tertiary hospital in riyadh
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d864dfbc7a3e4d45810e065fbc9a4e60
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Bacterial Profile and Antibiotic Susceptibility Pattern of Bacterial Keratitis at a Tertiary Hospital in Riyadh

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