Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy

Abstract Tungsten disulfide nanotubes (WS2-NTs) were found to be very active for photothermal therapy. However, their lack of stability in aqueous solutions inhibits their use in many applications, especially in biomedicine. Few attempts were made to chemically functionalize the surface of the NTs t...

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Autores principales:	Tzuriel Levin, Yakir Lampel, Gaya Savyon, Esthy Levy, Yifat Harel, Yuval Elias, Moshe Sinvani, Iftach Nachman, Jean-Paul Lellouche
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d8660a6e41cc4c4480651a2cfaa834c6
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spelling	oai:doaj.org-article:d8660a6e41cc4c4480651a2cfaa834c62021-12-02T18:14:16ZInnovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy10.1038/s41598-021-97052-62045-2322https://doaj.org/article/d8660a6e41cc4c4480651a2cfaa834c62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97052-6https://doaj.org/toc/2045-2322Abstract Tungsten disulfide nanotubes (WS2-NTs) were found to be very active for photothermal therapy. However, their lack of stability in aqueous solutions inhibits their use in many applications, especially in biomedicine. Few attempts were made to chemically functionalize the surface of the NTs to improve their dispersability. Here, we present a new polymerization method using cerium-doped maghemite nanoparticles (CM-NPs) as magnetic nanosized linkers between the WS2-NT surface and pyrrole-N-propionic acid monomers, which allow in situ polymerization onto the composite surface. This unique composite is magnetic, and contains two active entities for photothermal therapy—WS2 and the polypyrrole. The photothermal activity of the composite was tested at a wavelength of 808 nm, and significant thermal activity was observed. Moreover, the polycarboxylated polymeric coating of the NTs enables effective linkage of additional molecules or drugs via covalent bonding. In addition, a new method was established for large-scale synthesis of CM-NPs and WS2-NT-CM composites.Tzuriel LevinYakir LampelGaya SavyonEsthy LevyYifat HarelYuval EliasMoshe SinvaniIftach NachmanJean-Paul LelloucheNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tzuriel Levin Yakir Lampel Gaya Savyon Esthy Levy Yifat Harel Yuval Elias Moshe Sinvani Iftach Nachman Jean-Paul Lellouche Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy
description	Abstract Tungsten disulfide nanotubes (WS2-NTs) were found to be very active for photothermal therapy. However, their lack of stability in aqueous solutions inhibits their use in many applications, especially in biomedicine. Few attempts were made to chemically functionalize the surface of the NTs to improve their dispersability. Here, we present a new polymerization method using cerium-doped maghemite nanoparticles (CM-NPs) as magnetic nanosized linkers between the WS2-NT surface and pyrrole-N-propionic acid monomers, which allow in situ polymerization onto the composite surface. This unique composite is magnetic, and contains two active entities for photothermal therapy—WS2 and the polypyrrole. The photothermal activity of the composite was tested at a wavelength of 808 nm, and significant thermal activity was observed. Moreover, the polycarboxylated polymeric coating of the NTs enables effective linkage of additional molecules or drugs via covalent bonding. In addition, a new method was established for large-scale synthesis of CM-NPs and WS2-NT-CM composites.
format	article
author	Tzuriel Levin Yakir Lampel Gaya Savyon Esthy Levy Yifat Harel Yuval Elias Moshe Sinvani Iftach Nachman Jean-Paul Lellouche
author_facet	Tzuriel Levin Yakir Lampel Gaya Savyon Esthy Levy Yifat Harel Yuval Elias Moshe Sinvani Iftach Nachman Jean-Paul Lellouche
author_sort	Tzuriel Levin
title	Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy
title_short	Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy
title_full	Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy
title_fullStr	Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy
title_full_unstemmed	Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy
title_sort	innovative functional polymerization of pyrrole-n-propionic acid onto ws2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d8660a6e41cc4c4480651a2cfaa834c6
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Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using cerium-doped maghemite nanoparticles for photothermal therapy

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