Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey

Background: Most studies on health-related quality of life (HRQoL) in chronic kidney disease (CKD) focus on patients with end-stage kidney disease although they represent a small proportion of patients with CKD. We aimed to analyze HRQoL according to glomerular filtration rate (GFR) categories in a...

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Autores principales:	Liv Faulhaber, Stefan Herget-Rosenthal, Hannes Jacobs, Falk Hoffmann
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	health-related quality of life short form health survey-36 chronic kidney disease glomerular filtration rate Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/d86702cf2b9f4667b5a69893fbc5d3b7
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spelling	oai:doaj.org-article:d86702cf2b9f4667b5a69893fbc5d3b72021-12-02T12:40:22ZHealth-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey1420-40961423-014310.1159/000518668https://doaj.org/article/d86702cf2b9f4667b5a69893fbc5d3b72021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/518668https://doaj.org/toc/1420-4096https://doaj.org/toc/1423-0143Background: Most studies on health-related quality of life (HRQoL) in chronic kidney disease (CKD) focus on patients with end-stage kidney disease although they represent a small proportion of patients with CKD. We aimed to analyze HRQoL according to glomerular filtration rate (GFR) categories in a population-based sample of adults living in Germany. Methods: Data from the German health interview and examination survey conducted from 2008 to 2011 were used. Participants with valid interview and examination data aged 40–79 years were included (n = 5,159). Serum creatinine levels were used to calculate estimated GFR via the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. We classified kidney function in GFR categories according to the Kidney Disease Improving Global Outcomes Initiative (KDIGO) guidelines on CKD: G1 (high): ≥90 mL/min/1.73 m2, G2 (normal): 60–89 mL/min/1.73 m2, G3a (mildly decreased): 45–59 mL/min/1.73 m2, G3b (moderately decreased): 30–44 mL/min/1.73 m2, G4/5 (severely decreased/end-stage kidney disease): <30 mL/min/1.73 m2. HRQoL was evaluated with the Short Form Health Survey (SF-36). Different multivariate linear and logistic regression models were used to analyze the association of HRQoL with GFR categories. Results: Overall, 5.9% had a GFR <60 mL/min/1.73 m2 (corresponding to categories G3a, G3b, and G4/5). Compared to category G2 linear regression showed a decline in physical HRQoL in categories G3a (−2.34, p = 0.004), G3b (−5.37, p = 0.009), and G4/5 (−4.82, p = 0.117). No decline in mental HRQoL was detected with increasing GFR categories. Categories G3a to G4/5 were significantly associated with a low perceived general state of health (G3a: odds ratio [OR] = 2.03, p = 0.001; G3b: OR = 3.01, p = 0.009; G4/5: OR = 8.70, p = 0.016) when compared to category G2. Conclusion: In a representative sample of adults living in Germany, both physical HRQoL and the perceived general state of health are already significantly reduced in category G3a.Liv FaulhaberStefan Herget-RosenthalHannes JacobsFalk HoffmannKarger Publishersarticlehealth-related quality of lifeshort form health survey-36chronic kidney diseaseglomerular filtration rateDermatologyRL1-803Diseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the genitourinary system. UrologyRC870-923ENKidney & Blood Pressure Research, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	health-related quality of life short form health survey-36 chronic kidney disease glomerular filtration rate Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	health-related quality of life short form health survey-36 chronic kidney disease glomerular filtration rate Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923 Liv Faulhaber Stefan Herget-Rosenthal Hannes Jacobs Falk Hoffmann Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
description	Background: Most studies on health-related quality of life (HRQoL) in chronic kidney disease (CKD) focus on patients with end-stage kidney disease although they represent a small proportion of patients with CKD. We aimed to analyze HRQoL according to glomerular filtration rate (GFR) categories in a population-based sample of adults living in Germany. Methods: Data from the German health interview and examination survey conducted from 2008 to 2011 were used. Participants with valid interview and examination data aged 40–79 years were included (n = 5,159). Serum creatinine levels were used to calculate estimated GFR via the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. We classified kidney function in GFR categories according to the Kidney Disease Improving Global Outcomes Initiative (KDIGO) guidelines on CKD: G1 (high): ≥90 mL/min/1.73 m2, G2 (normal): 60–89 mL/min/1.73 m2, G3a (mildly decreased): 45–59 mL/min/1.73 m2, G3b (moderately decreased): 30–44 mL/min/1.73 m2, G4/5 (severely decreased/end-stage kidney disease): <30 mL/min/1.73 m2. HRQoL was evaluated with the Short Form Health Survey (SF-36). Different multivariate linear and logistic regression models were used to analyze the association of HRQoL with GFR categories. Results: Overall, 5.9% had a GFR <60 mL/min/1.73 m2 (corresponding to categories G3a, G3b, and G4/5). Compared to category G2 linear regression showed a decline in physical HRQoL in categories G3a (−2.34, p = 0.004), G3b (−5.37, p = 0.009), and G4/5 (−4.82, p = 0.117). No decline in mental HRQoL was detected with increasing GFR categories. Categories G3a to G4/5 were significantly associated with a low perceived general state of health (G3a: odds ratio [OR] = 2.03, p = 0.001; G3b: OR = 3.01, p = 0.009; G4/5: OR = 8.70, p = 0.016) when compared to category G2. Conclusion: In a representative sample of adults living in Germany, both physical HRQoL and the perceived general state of health are already significantly reduced in category G3a.
format	article
author	Liv Faulhaber Stefan Herget-Rosenthal Hannes Jacobs Falk Hoffmann
author_facet	Liv Faulhaber Stefan Herget-Rosenthal Hannes Jacobs Falk Hoffmann
author_sort	Liv Faulhaber
title	Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
title_short	Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
title_full	Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
title_fullStr	Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
title_full_unstemmed	Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
title_sort	health-related quality of life according to renal function: results from a nationwide health interview and examination survey
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/d86702cf2b9f4667b5a69893fbc5d3b7
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Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey

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