Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene

The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX complex to act on two enhancer elements of the CD4...

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Autores principales:	Satoshi Kojo, Nighat Yasmin, Sawako Muroi, Mari Tenno, Ichiro Taniuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d86726caf6ce4de0928acd1231b62010
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id	oai:doaj.org-article:d86726caf6ce4de0928acd1231b62010
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spelling	oai:doaj.org-article:d86726caf6ce4de0928acd1231b620102021-12-02T16:49:48ZRunx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene10.1038/s41467-018-05803-32041-1723https://doaj.org/article/d86726caf6ce4de0928acd1231b620102018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05803-3https://doaj.org/toc/2041-1723The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX complex to act on two enhancer elements of the CD4 gene to control T cell lineage commitment in the thymus.Satoshi KojoNighat YasminSawako MuroiMari TennoIchiro TaniuchiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satoshi Kojo Nighat Yasmin Sawako Muroi Mari Tenno Ichiro Taniuchi Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
description	The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX complex to act on two enhancer elements of the CD4 gene to control T cell lineage commitment in the thymus.
format	article
author	Satoshi Kojo Nighat Yasmin Sawako Muroi Mari Tenno Ichiro Taniuchi
author_facet	Satoshi Kojo Nighat Yasmin Sawako Muroi Mari Tenno Ichiro Taniuchi
author_sort	Satoshi Kojo
title	Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
title_short	Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
title_full	Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
title_fullStr	Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
title_full_unstemmed	Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
title_sort	runx-dependent and silencer-independent repression of a maturation enhancer in the cd4 gene
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d86726caf6ce4de0928acd1231b62010
work_keys_str_mv	AT satoshikojo runxdependentandsilencerindependentrepressionofamaturationenhancerinthecd4gene AT nighatyasmin runxdependentandsilencerindependentrepressionofamaturationenhancerinthecd4gene AT sawakomuroi runxdependentandsilencerindependentrepressionofamaturationenhancerinthecd4gene AT maritenno runxdependentandsilencerindependentrepressionofamaturationenhancerinthecd4gene AT ichirotaniuchi runxdependentandsilencerindependentrepressionofamaturationenhancerinthecd4gene
_version_	1718383243872436224

Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene

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