RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA
MAVS and MITA are adapter proteins that play distinct roles in the context of the host response to RNA and DNA viruses, respectively. Here the authors implicate RNF115 in dual temporal and spatial mechanisms of interacting and catalyzing distinct ubiquitination of MAVS and MITA to modulate RNA and D...
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2020
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oai:doaj.org-article:d86849cb360d49c3b4f0cb43df17139e2021-12-02T15:39:12ZRNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA10.1038/s41467-020-19318-32041-1723https://doaj.org/article/d86849cb360d49c3b4f0cb43df17139e2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19318-3https://doaj.org/toc/2041-1723MAVS and MITA are adapter proteins that play distinct roles in the context of the host response to RNA and DNA viruses, respectively. Here the authors implicate RNF115 in dual temporal and spatial mechanisms of interacting and catalyzing distinct ubiquitination of MAVS and MITA to modulate RNA and DNA antiviral immune responses.Zhi-Dong ZhangTian-Chen XiongShu-Qi YaoMing-Cong WeiMing ChenDandan LinBo ZhongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
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Science Q Zhi-Dong Zhang Tian-Chen Xiong Shu-Qi Yao Ming-Cong Wei Ming Chen Dandan Lin Bo Zhong RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA |
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MAVS and MITA are adapter proteins that play distinct roles in the context of the host response to RNA and DNA viruses, respectively. Here the authors implicate RNF115 in dual temporal and spatial mechanisms of interacting and catalyzing distinct ubiquitination of MAVS and MITA to modulate RNA and DNA antiviral immune responses. |
format |
article |
author |
Zhi-Dong Zhang Tian-Chen Xiong Shu-Qi Yao Ming-Cong Wei Ming Chen Dandan Lin Bo Zhong |
author_facet |
Zhi-Dong Zhang Tian-Chen Xiong Shu-Qi Yao Ming-Cong Wei Ming Chen Dandan Lin Bo Zhong |
author_sort |
Zhi-Dong Zhang |
title |
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA |
title_short |
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA |
title_full |
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA |
title_fullStr |
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA |
title_full_unstemmed |
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA |
title_sort |
rnf115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of mavs and mita |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/d86849cb360d49c3b4f0cb43df17139e |
work_keys_str_mv |
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