Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts. Here the authors provide insight into the role of endogenous NAD+ metabolism by studying n...

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Autores principales:	Audrey Sambeat, Joanna Ratajczak, Magali Joffraud, José L. Sanchez-Garcia, Maria P. Giner, Armand Valsesia, Judith Giroud-Gerbetant, Miriam Valera-Alberni, Angelique Cercillieux, Marie Boutant, Sameer S. Kulkarni, Sofia Moco, Carles Canto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d868646ab078447ea44fb258c12312d5
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spelling	oai:doaj.org-article:d868646ab078447ea44fb258c12312d52021-12-02T14:38:38ZEndogenous nicotinamide riboside metabolism protects against diet-induced liver damage10.1038/s41467-019-12262-x2041-1723https://doaj.org/article/d868646ab078447ea44fb258c12312d52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12262-xhttps://doaj.org/toc/2041-1723Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts. Here the authors provide insight into the role of endogenous NAD+ metabolism by studying nicotinamide riboside kinase 1 (NRK1) deficient mice.Audrey SambeatJoanna RatajczakMagali JoffraudJosé L. Sanchez-GarciaMaria P. GinerArmand ValsesiaJudith Giroud-GerbetantMiriam Valera-AlberniAngelique CercillieuxMarie BoutantSameer S. KulkarniSofia MocoCarles CantoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Audrey Sambeat Joanna Ratajczak Magali Joffraud José L. Sanchez-Garcia Maria P. Giner Armand Valsesia Judith Giroud-Gerbetant Miriam Valera-Alberni Angelique Cercillieux Marie Boutant Sameer S. Kulkarni Sofia Moco Carles Canto Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
description	Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts. Here the authors provide insight into the role of endogenous NAD+ metabolism by studying nicotinamide riboside kinase 1 (NRK1) deficient mice.
format	article
author	Audrey Sambeat Joanna Ratajczak Magali Joffraud José L. Sanchez-Garcia Maria P. Giner Armand Valsesia Judith Giroud-Gerbetant Miriam Valera-Alberni Angelique Cercillieux Marie Boutant Sameer S. Kulkarni Sofia Moco Carles Canto
author_facet	Audrey Sambeat Joanna Ratajczak Magali Joffraud José L. Sanchez-Garcia Maria P. Giner Armand Valsesia Judith Giroud-Gerbetant Miriam Valera-Alberni Angelique Cercillieux Marie Boutant Sameer S. Kulkarni Sofia Moco Carles Canto
author_sort	Audrey Sambeat
title	Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
title_short	Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
title_full	Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
title_fullStr	Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
title_full_unstemmed	Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
title_sort	endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d868646ab078447ea44fb258c12312d5
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Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

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