Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.

<h4>Background</h4>The occurrence of Parkinson's disease (PD) is known to be associated both with increased nigrostriatal iron content and with low serum cholesterol and PD, but there has been no study to determine a potential relationship between these two factors.<h4>Methods...

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Autores principales:	Guangwei Du, Mechelle M Lewis, Michele L Shaffer, Honglei Chen, Qing X Yang, Richard B Mailman, Xuemei Huang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d86a822c7fff4264a19f7f2a6d21b634
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spelling	oai:doaj.org-article:d86a822c7fff4264a19f7f2a6d21b6342021-11-18T07:21:54ZSerum cholesterol and nigrostriatal R2* values in Parkinson's disease.1932-620310.1371/journal.pone.0035397https://doaj.org/article/d86a822c7fff4264a19f7f2a6d21b6342012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22530017/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The occurrence of Parkinson's disease (PD) is known to be associated both with increased nigrostriatal iron content and with low serum cholesterol and PD, but there has been no study to determine a potential relationship between these two factors.<h4>Methods</h4>High-resolution MRI (T1-, T2, and multiple echo T2-weighted imaging) and fasting lipid levels were obtained from 40 patients with PD and 29 healthy controls. Iron content was estimated from mean R2 values (R2* = 1/T2*) calculated for each nigrostriatal structure including substantia nigra, caudate, putamen, and globus pallidus. This was correlated with serum cholesterol levels after controlling for age, gender, and statin use.<h4>Results</h4>In patients with PD, higher serum cholesterol levels were associated with lower iron content in the substantia nigra (R = -0.43, p = 0.011 for total-cholesterol, R = -0.31, p = 0.080 for low-density lipoprotein) and globus pallidus (R = -0.38, p = 0.028 for total-cholesterol, R = -0.27, p = 0.127 for low-density lipoprotein), but only a trend toward significant association of higher total-cholesterol with lower iron content in the striatum (R = -0.34, p = 0.052 for caudate; R = -0.32, p = 0.061 for putamen). After adjusting for clinical measures, the cholesterol-iron relationships held or became even stronger in the substantia nigra and globus pallidus, but weaker in the caudate and putamen. There was no significant association between serum cholesterol levels and nigrostriatal iron content for controls.<h4>Conclusions</h4>The data show that higher serum total-cholesterol concentration is associated with lower iron content in substantia nigra and globus pallidus in Parkinson's disease patients. Further studies should investigate whether this is mechanistic or epiphenomenological relationship.Guangwei DuMechelle M LewisMichele L ShafferHonglei ChenQing X YangRichard B MailmanXuemei HuangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35397 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guangwei Du Mechelle M Lewis Michele L Shaffer Honglei Chen Qing X Yang Richard B Mailman Xuemei Huang Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.
description	<h4>Background</h4>The occurrence of Parkinson's disease (PD) is known to be associated both with increased nigrostriatal iron content and with low serum cholesterol and PD, but there has been no study to determine a potential relationship between these two factors.<h4>Methods</h4>High-resolution MRI (T1-, T2, and multiple echo T2-weighted imaging) and fasting lipid levels were obtained from 40 patients with PD and 29 healthy controls. Iron content was estimated from mean R2 values (R2* = 1/T2*) calculated for each nigrostriatal structure including substantia nigra, caudate, putamen, and globus pallidus. This was correlated with serum cholesterol levels after controlling for age, gender, and statin use.<h4>Results</h4>In patients with PD, higher serum cholesterol levels were associated with lower iron content in the substantia nigra (R = -0.43, p = 0.011 for total-cholesterol, R = -0.31, p = 0.080 for low-density lipoprotein) and globus pallidus (R = -0.38, p = 0.028 for total-cholesterol, R = -0.27, p = 0.127 for low-density lipoprotein), but only a trend toward significant association of higher total-cholesterol with lower iron content in the striatum (R = -0.34, p = 0.052 for caudate; R = -0.32, p = 0.061 for putamen). After adjusting for clinical measures, the cholesterol-iron relationships held or became even stronger in the substantia nigra and globus pallidus, but weaker in the caudate and putamen. There was no significant association between serum cholesterol levels and nigrostriatal iron content for controls.<h4>Conclusions</h4>The data show that higher serum total-cholesterol concentration is associated with lower iron content in substantia nigra and globus pallidus in Parkinson's disease patients. Further studies should investigate whether this is mechanistic or epiphenomenological relationship.
format	article
author	Guangwei Du Mechelle M Lewis Michele L Shaffer Honglei Chen Qing X Yang Richard B Mailman Xuemei Huang
author_facet	Guangwei Du Mechelle M Lewis Michele L Shaffer Honglei Chen Qing X Yang Richard B Mailman Xuemei Huang
author_sort	Guangwei Du
title	Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.
title_short	Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.
title_full	Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.
title_fullStr	Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.
title_full_unstemmed	Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.
title_sort	serum cholesterol and nigrostriatal r2* values in parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d86a822c7fff4264a19f7f2a6d21b634
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Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.

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