RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome

Multiple organ dysfunction syndrome (MODS) is a serious event that can occur following infection or tissue injury, and is partly mediated by histones released in circulation. Here, the authors develop aptamers that neutralise histones involved in MODS, and demonstrate efficacy in human cells and in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kevin T. Urak, Giselle N. Blanco, Shambhavi Shubham, Li-Hsien Lin, Justin P. Dassie, William H. Thiel, Yani Chen, Vijay Kumar Sonkar, Beilei Lei, Shubha Murthy, Wade R. Gutierrez, Mary E. Wilson, Jonathan A. Stiber, Julia Klesney-Tait, Sanjana Dayal, Francis J. Miller, Paloma H. Giangrande
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d86b6e4d36f645ec80b0587ff0507135
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d86b6e4d36f645ec80b0587ff0507135
record_format	dspace
spelling	oai:doaj.org-article:d86b6e4d36f645ec80b0587ff05071352021-12-02T15:35:52ZRNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome10.1038/s41467-018-08030-y2041-1723https://doaj.org/article/d86b6e4d36f645ec80b0587ff05071352019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08030-yhttps://doaj.org/toc/2041-1723Multiple organ dysfunction syndrome (MODS) is a serious event that can occur following infection or tissue injury, and is partly mediated by histones released in circulation. Here, the authors develop aptamers that neutralise histones involved in MODS, and demonstrate efficacy in human cells and in mouse models.Kevin T. UrakGiselle N. BlancoShambhavi ShubhamLi-Hsien LinJustin P. DassieWilliam H. ThielYani ChenVijay Kumar SonkarBeilei LeiShubha MurthyWade R. GutierrezMary E. WilsonJonathan A. StiberJulia Klesney-TaitSanjana DayalFrancis J. MillerPaloma H. GiangrandeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin T. Urak Giselle N. Blanco Shambhavi Shubham Li-Hsien Lin Justin P. Dassie William H. Thiel Yani Chen Vijay Kumar Sonkar Beilei Lei Shubha Murthy Wade R. Gutierrez Mary E. Wilson Jonathan A. Stiber Julia Klesney-Tait Sanjana Dayal Francis J. Miller Paloma H. Giangrande RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
description	Multiple organ dysfunction syndrome (MODS) is a serious event that can occur following infection or tissue injury, and is partly mediated by histones released in circulation. Here, the authors develop aptamers that neutralise histones involved in MODS, and demonstrate efficacy in human cells and in mouse models.
format	article
author	Kevin T. Urak Giselle N. Blanco Shambhavi Shubham Li-Hsien Lin Justin P. Dassie William H. Thiel Yani Chen Vijay Kumar Sonkar Beilei Lei Shubha Murthy Wade R. Gutierrez Mary E. Wilson Jonathan A. Stiber Julia Klesney-Tait Sanjana Dayal Francis J. Miller Paloma H. Giangrande
author_facet	Kevin T. Urak Giselle N. Blanco Shambhavi Shubham Li-Hsien Lin Justin P. Dassie William H. Thiel Yani Chen Vijay Kumar Sonkar Beilei Lei Shubha Murthy Wade R. Gutierrez Mary E. Wilson Jonathan A. Stiber Julia Klesney-Tait Sanjana Dayal Francis J. Miller Paloma H. Giangrande
author_sort	Kevin T. Urak
title	RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
title_short	RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
title_full	RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
title_fullStr	RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
title_full_unstemmed	RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
title_sort	rna inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d86b6e4d36f645ec80b0587ff0507135
work_keys_str_mv	AT kevinturak rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT gisellenblanco rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT shambhavishubham rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT lihsienlin rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT justinpdassie rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT williamhthiel rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT yanichen rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT vijaykumarsonkar rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT beileilei rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT shubhamurthy rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT wadergutierrez rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT maryewilson rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT jonathanastiber rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT juliaklesneytait rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT sanjanadayal rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT francisjmiller rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome AT palomahgiangrande rnainhibitorsofnuclearproteinsresponsibleformultipleorgandysfunctionsyndrome
_version_	1718386443236147200

RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome

Ejemplares similares