Identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a life-threatening illness and ferroptosis is an iron-dependent form of regulated cell death, driven by the accumulation of lipid peroxides to levels that are sufficient to trigger cell death. However, only few studies have examined PAH-associated ferroptosis...

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Autores principales:	Fan Zhang, Hongtao Liu
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	pulmonary arterial hypertension ferroptosis ferrdb mirna tfs Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/d86c463f418741a8994e5b2ef8c40752
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spelling	oai:doaj.org-article:d86c463f418741a8994e5b2ef8c407522021-11-23T02:25:41ZIdentification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension10.3934/mbe.20213771551-0018https://doaj.org/article/d86c463f418741a8994e5b2ef8c407522021-09-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021377?viewType=HTMLhttps://doaj.org/toc/1551-0018Pulmonary arterial hypertension (PAH) is a life-threatening illness and ferroptosis is an iron-dependent form of regulated cell death, driven by the accumulation of lipid peroxides to levels that are sufficient to trigger cell death. However, only few studies have examined PAH-associated ferroptosis. In the present study, lung samples mRNA expression profiles (derived from 15 patients with PAH and 11 normal controls) were downloaded from a public database, and 514 differentially expressed genes (DEGs) were identified using the Wilcoxon rank-sum test and weighted gene correlation network analyses. These DEGs were screened for ferroptosis-associated genes using the FerrDb database: eight ferroptosis-associated genes were identified. Finally, the construction of gene-microRNA (miRNA) and gene-transcription factor (TF) networks, in conjunction with gene ontology and biological pathway enrichment analysis, were used to inform hypotheses regarding the molecular mechanisms underlying PAH-associated ferroptosis. Ferroptosis-associated genes were largely involved in oxidative stress responses and could be regulated by several identified miRNAs and TFs. This suggests the existence of modulatable pathways that are potentially involved in PAH-associated ferroptosis. Our findings provide novel directions for targeted therapy of PAH in regard to ferroptosis. These findings may ultimately help improve the therapeutic outcomes of PAH.Fan ZhangHongtao LiuAIMS Pressarticlepulmonary arterial hypertensionferroptosisferrdbmirnatfsBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 7619-7630 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pulmonary arterial hypertension ferroptosis ferrdb mirna tfs Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	pulmonary arterial hypertension ferroptosis ferrdb mirna tfs Biotechnology TP248.13-248.65 Mathematics QA1-939 Fan Zhang Hongtao Liu Identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension
description	Pulmonary arterial hypertension (PAH) is a life-threatening illness and ferroptosis is an iron-dependent form of regulated cell death, driven by the accumulation of lipid peroxides to levels that are sufficient to trigger cell death. However, only few studies have examined PAH-associated ferroptosis. In the present study, lung samples mRNA expression profiles (derived from 15 patients with PAH and 11 normal controls) were downloaded from a public database, and 514 differentially expressed genes (DEGs) were identified using the Wilcoxon rank-sum test and weighted gene correlation network analyses. These DEGs were screened for ferroptosis-associated genes using the FerrDb database: eight ferroptosis-associated genes were identified. Finally, the construction of gene-microRNA (miRNA) and gene-transcription factor (TF) networks, in conjunction with gene ontology and biological pathway enrichment analysis, were used to inform hypotheses regarding the molecular mechanisms underlying PAH-associated ferroptosis. Ferroptosis-associated genes were largely involved in oxidative stress responses and could be regulated by several identified miRNAs and TFs. This suggests the existence of modulatable pathways that are potentially involved in PAH-associated ferroptosis. Our findings provide novel directions for targeted therapy of PAH in regard to ferroptosis. These findings may ultimately help improve the therapeutic outcomes of PAH.
format	article
author	Fan Zhang Hongtao Liu
author_facet	Fan Zhang Hongtao Liu
author_sort	Fan Zhang
title	Identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension
title_short	Identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension
title_full	Identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension
title_fullStr	Identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension
title_full_unstemmed	Identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension
title_sort	identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/d86c463f418741a8994e5b2ef8c40752
work_keys_str_mv	AT fanzhang identificationofferroptosisassociatedgenesexhibitingalteredexpressioninpulmonaryarterialhypertension AT hongtaoliu identificationofferroptosisassociatedgenesexhibitingalteredexpressioninpulmonaryarterialhypertension
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Identification of ferroptosis-associated genes exhibiting altered expression in pulmonary arterial hypertension

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