mTOR pathway: A potential therapeutic target for spinal cord injury

Spinal cord injury (SCI) is the most common disabling spinal injury, and the complex pathological process can eventually lead to severe neurological dysfunction. Many studies have reported that the mammalian target of rapamycin (mTOR) signaling pathway plays an important role in synaptogenesis, neur...

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Autores principales:	Yi Ding, Qin Chen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Spinal cord injury (SCI) mTOR pathway Nerve recovery Glial scar Therapeutic targets Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d86ca21daf634affb8462a81f2b16be1
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spelling	oai:doaj.org-article:d86ca21daf634affb8462a81f2b16be12021-11-20T04:55:52ZmTOR pathway: A potential therapeutic target for spinal cord injury0753-332210.1016/j.biopha.2021.112430https://doaj.org/article/d86ca21daf634affb8462a81f2b16be12022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012166https://doaj.org/toc/0753-3322Spinal cord injury (SCI) is the most common disabling spinal injury, and the complex pathological process can eventually lead to severe neurological dysfunction. Many studies have reported that the mammalian target of rapamycin (mTOR) signaling pathway plays an important role in synaptogenesis, neuron growth, differentiation, and survival after central nervous system injury. It is also involved in various traumatic and central nervous system diseases, including traumatic brain injury, neonatal hypoxic-ischemic brain injury, Alzheimer's disease, Parkinson's disease, and cerebral apoplexy. mTOR has also been reported to play an important regulatory role in various pathophysiological processes following SCI. Activation of mTOR signals after SCI can regulate physiological and pathological processes, such as proliferation and differentiation of neural stem cells, regeneration of nerve axons, neuroinflammation, and glial scar formation, through various pathways. Inhibition of mTOR activity has been confirmed to promote repair in SCI. At present, many studies have reported that Chinese herbal medicine can inhibit the SCI-activated mTOR pathway to improve the microenvironment and promote nerve repair after SCI. Due to the role of the mTOR pathway in SCI, it may be a potential therapeutic target for SCI. This review is focused on the pathophysiological process of SCI, characteristics of the mTOR pathway, role of the mTOR pathway in SCI, role of inhibition of mTOR on SCI, and role and significance of inhibition of mTOR by related Chinese herbal medicine inhibitors in SCI. In addition, the review discusses the deficiencies and solutions to mTOR and SCI research shortcomings. This study hopes to provide reference for mTOR and SCI research and a theoretical basis for SCI biotherapy.Yi DingQin ChenElsevierarticleSpinal cord injury (SCI)mTOR pathwayNerve recoveryGlial scarTherapeutic targetsTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112430- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spinal cord injury (SCI) mTOR pathway Nerve recovery Glial scar Therapeutic targets Therapeutics. Pharmacology RM1-950
spellingShingle	Spinal cord injury (SCI) mTOR pathway Nerve recovery Glial scar Therapeutic targets Therapeutics. Pharmacology RM1-950 Yi Ding Qin Chen mTOR pathway: A potential therapeutic target for spinal cord injury
description	Spinal cord injury (SCI) is the most common disabling spinal injury, and the complex pathological process can eventually lead to severe neurological dysfunction. Many studies have reported that the mammalian target of rapamycin (mTOR) signaling pathway plays an important role in synaptogenesis, neuron growth, differentiation, and survival after central nervous system injury. It is also involved in various traumatic and central nervous system diseases, including traumatic brain injury, neonatal hypoxic-ischemic brain injury, Alzheimer's disease, Parkinson's disease, and cerebral apoplexy. mTOR has also been reported to play an important regulatory role in various pathophysiological processes following SCI. Activation of mTOR signals after SCI can regulate physiological and pathological processes, such as proliferation and differentiation of neural stem cells, regeneration of nerve axons, neuroinflammation, and glial scar formation, through various pathways. Inhibition of mTOR activity has been confirmed to promote repair in SCI. At present, many studies have reported that Chinese herbal medicine can inhibit the SCI-activated mTOR pathway to improve the microenvironment and promote nerve repair after SCI. Due to the role of the mTOR pathway in SCI, it may be a potential therapeutic target for SCI. This review is focused on the pathophysiological process of SCI, characteristics of the mTOR pathway, role of the mTOR pathway in SCI, role of inhibition of mTOR on SCI, and role and significance of inhibition of mTOR by related Chinese herbal medicine inhibitors in SCI. In addition, the review discusses the deficiencies and solutions to mTOR and SCI research shortcomings. This study hopes to provide reference for mTOR and SCI research and a theoretical basis for SCI biotherapy.
format	article
author	Yi Ding Qin Chen
author_facet	Yi Ding Qin Chen
author_sort	Yi Ding
title	mTOR pathway: A potential therapeutic target for spinal cord injury
title_short	mTOR pathway: A potential therapeutic target for spinal cord injury
title_full	mTOR pathway: A potential therapeutic target for spinal cord injury
title_fullStr	mTOR pathway: A potential therapeutic target for spinal cord injury
title_full_unstemmed	mTOR pathway: A potential therapeutic target for spinal cord injury
title_sort	mtor pathway: a potential therapeutic target for spinal cord injury
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/d86ca21daf634affb8462a81f2b16be1
work_keys_str_mv	AT yiding mtorpathwayapotentialtherapeutictargetforspinalcordinjury AT qinchen mtorpathwayapotentialtherapeutictargetforspinalcordinjury
_version_	1718419744356302848

mTOR pathway: A potential therapeutic target for spinal cord injury

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