Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia

Abstract In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10−/− mice. Using western blotting, immunofluorescence, ELISA and qRT-...

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Auteurs principaux: Mancy Tong, Shi-bin Cheng, Qi Chen, Joana DeSousa, Peter R. Stone, Joanna L. James, Lawrence W. Chamley, Surendra Sharma
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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R
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Accès en ligne:https://doaj.org/article/d86da9a98d17490480dbca830c152fcc
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