High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.

Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among c...

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Autores principales:	Heng Yang, Yang Yang, Zhi-Dong Hu, Lu Xia, Xu-Hui Liu, Xin Yu, Jia-Ye Ma, Tao Li, Shui-Hua Lu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d870e0a6b3914df782c79e3639dbd6f6
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spelling	oai:doaj.org-article:d870e0a6b3914df782c79e3639dbd6f62021-12-02T20:10:44ZHigh rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.1932-620310.1371/journal.pone.0253159https://doaj.org/article/d870e0a6b3914df782c79e3639dbd6f62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253159https://doaj.org/toc/1932-6203Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among children in China. Participants aged 1-14 years receiving 3HP for TB prevention at Shanghai Public Health Clinical Center were followed from December 2019 to November 2020 to evaluate the safety and completion rate of the treatment. Thirty-one children were eligible for inclusion, but five were excluded from the analysis (three were treated with a lower than recommended dose, and two were lost to follow-up). Of the 26 children included in the analysis, the treatment completion rate was 100%. Adverse drug reactions (ADRs) were reported in 38.5% (10/26) of the patients. The most common ADRs were gastrointestinal symptoms (19.2%,5/26), and all ADRs were rated as Grade 1. The 3HP regimen has a high completion rate, and it seems well tolerated in our study population. However, further randomized controlled clinical trial with larger sample size are warranted.Heng YangYang YangZhi-Dong HuLu XiaXu-Hui LiuXin YuJia-Ye MaTao LiShui-Hua LuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253159 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heng Yang Yang Yang Zhi-Dong Hu Lu Xia Xu-Hui Liu Xin Yu Jia-Ye Ma Tao Li Shui-Hua Lu High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.
description	Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among children in China. Participants aged 1-14 years receiving 3HP for TB prevention at Shanghai Public Health Clinical Center were followed from December 2019 to November 2020 to evaluate the safety and completion rate of the treatment. Thirty-one children were eligible for inclusion, but five were excluded from the analysis (three were treated with a lower than recommended dose, and two were lost to follow-up). Of the 26 children included in the analysis, the treatment completion rate was 100%. Adverse drug reactions (ADRs) were reported in 38.5% (10/26) of the patients. The most common ADRs were gastrointestinal symptoms (19.2%,5/26), and all ADRs were rated as Grade 1. The 3HP regimen has a high completion rate, and it seems well tolerated in our study population. However, further randomized controlled clinical trial with larger sample size are warranted.
format	article
author	Heng Yang Yang Yang Zhi-Dong Hu Lu Xia Xu-Hui Liu Xin Yu Jia-Ye Ma Tao Li Shui-Hua Lu
author_facet	Heng Yang Yang Yang Zhi-Dong Hu Lu Xia Xu-Hui Liu Xin Yu Jia-Ye Ma Tao Li Shui-Hua Lu
author_sort	Heng Yang
title	High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.
title_short	High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.
title_full	High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.
title_fullStr	High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.
title_full_unstemmed	High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.
title_sort	high rate of completion for weekly rifapentine plus isoniazid treatment in chinese children with latent tuberculosis infection-a single center study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d870e0a6b3914df782c79e3639dbd6f6
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High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.

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