Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients

Background Fatty acid binding protein 4 (FABP4) is an adipokine that was mainly derived from adipocytes and macrophages. Vascular calcification (VC) is highly prevalent in peritoneal dialysis (PD) patients and could predict their cardiovascular mortality. The pathogenesis of VC is complex, and adipo...

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Autores principales:	Sijia Zhou, Xiaoxiao Wang, Junbao Shi, Qingfeng Han, Lian He, Wen Tang, Aihua Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	adipokine fabp4 peritoneal dialysis vascular calcification ckd-mbd Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/d874a7f3aafa469e864c0a8367ab2970
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spelling	oai:doaj.org-article:d874a7f3aafa469e864c0a8367ab29702021-11-26T11:19:46ZSerum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients0886-022X1525-604910.1080/0886022X.2021.2003205https://doaj.org/article/d874a7f3aafa469e864c0a8367ab29702021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/0886022X.2021.2003205https://doaj.org/toc/0886-022Xhttps://doaj.org/toc/1525-6049Background Fatty acid binding protein 4 (FABP4) is an adipokine that was mainly derived from adipocytes and macrophages. Vascular calcification (VC) is highly prevalent in peritoneal dialysis (PD) patients and could predict their cardiovascular mortality. The pathogenesis of VC is complex, and adipokines may play an important role in it. This study aimed to examine the relationship between serum FABP4 and VC in PD patients. Methods Serum FABP4 was measured by enzyme-linked immunosorbent assay. According to the median value of serum FABP4, the participants were divided into the low FABP4 group and the high FABP4 group. Lateral plain X-ray films of abdomen were used to evaluate the abdominal aortic calcification (AAC) score. The participants were divided into the high AAC score group (AAC score ≥4, indicating moderate or heavy VC) and the low AAC score group (AAC score <4, indicating no or mild VC). Results 116 PD patients were involved in the study. The AAC score and the proportion of patients with an AAC score ≥4 of the high FABP4 group were significantly higher than those of the low FABP4 group. Serum FABP4 of the high AAC score group was significantly higher than that of the low AAC score group [164.5 (138.4, 362.8) ng/mL versus 144.7 (123.8, 170.1) ng/mL, p = 0.002]. Serum FABP4 was positively associated with the AAC score according to the multivariate linear regression analysis. In the multivariate logistic regression analysis, serum FABP4 was the independent influencer of an AAC score ≥4. Conclusions Serum FABP4 is positively associated with the AAC score and is an independent marker of AAC in PD patients.Sijia ZhouXiaoxiao WangJunbao ShiQingfeng HanLian HeWen TangAihua ZhangTaylor & Francis Grouparticleadipokinefabp4peritoneal dialysisvascular calcificationckd-mbdDiseases of the genitourinary system. UrologyRC870-923ENRenal Failure, Vol 43, Iss 1, Pp 1539-1548 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipokine fabp4 peritoneal dialysis vascular calcification ckd-mbd Diseases of the genitourinary system. Urology RC870-923
spellingShingle	adipokine fabp4 peritoneal dialysis vascular calcification ckd-mbd Diseases of the genitourinary system. Urology RC870-923 Sijia Zhou Xiaoxiao Wang Junbao Shi Qingfeng Han Lian He Wen Tang Aihua Zhang Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients
description	Background Fatty acid binding protein 4 (FABP4) is an adipokine that was mainly derived from adipocytes and macrophages. Vascular calcification (VC) is highly prevalent in peritoneal dialysis (PD) patients and could predict their cardiovascular mortality. The pathogenesis of VC is complex, and adipokines may play an important role in it. This study aimed to examine the relationship between serum FABP4 and VC in PD patients. Methods Serum FABP4 was measured by enzyme-linked immunosorbent assay. According to the median value of serum FABP4, the participants were divided into the low FABP4 group and the high FABP4 group. Lateral plain X-ray films of abdomen were used to evaluate the abdominal aortic calcification (AAC) score. The participants were divided into the high AAC score group (AAC score ≥4, indicating moderate or heavy VC) and the low AAC score group (AAC score <4, indicating no or mild VC). Results 116 PD patients were involved in the study. The AAC score and the proportion of patients with an AAC score ≥4 of the high FABP4 group were significantly higher than those of the low FABP4 group. Serum FABP4 of the high AAC score group was significantly higher than that of the low AAC score group [164.5 (138.4, 362.8) ng/mL versus 144.7 (123.8, 170.1) ng/mL, p = 0.002]. Serum FABP4 was positively associated with the AAC score according to the multivariate linear regression analysis. In the multivariate logistic regression analysis, serum FABP4 was the independent influencer of an AAC score ≥4. Conclusions Serum FABP4 is positively associated with the AAC score and is an independent marker of AAC in PD patients.
format	article
author	Sijia Zhou Xiaoxiao Wang Junbao Shi Qingfeng Han Lian He Wen Tang Aihua Zhang
author_facet	Sijia Zhou Xiaoxiao Wang Junbao Shi Qingfeng Han Lian He Wen Tang Aihua Zhang
author_sort	Sijia Zhou
title	Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients
title_short	Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients
title_full	Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients
title_fullStr	Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients
title_full_unstemmed	Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients
title_sort	serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/d874a7f3aafa469e864c0a8367ab2970
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Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients

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