Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia

Abstract Iron deficiency anaemia (IDA) is common in colorectal cancer (CRC), especially, in right-sided CRC which is known to have an overall worse prognosis. The associations between diagnostic pathway (Bowel Cancer Screening Programme (BCSP), IDA, symptomatic) and tumour side/stage was assessed us...

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Autores principales:	Orouba Almilaji, Sally D. Parry, Sharon Docherty, Jonathon Snook
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d8762b0ad70641a8bc66b69642564f86
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spelling	oai:doaj.org-article:d8762b0ad70641a8bc66b69642564f862021-12-02T17:14:24ZEvidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia10.1038/s41598-021-92623-z2045-2322https://doaj.org/article/d8762b0ad70641a8bc66b69642564f862021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92623-zhttps://doaj.org/toc/2045-2322Abstract Iron deficiency anaemia (IDA) is common in colorectal cancer (CRC), especially, in right-sided CRC which is known to have an overall worse prognosis. The associations between diagnostic pathway (Bowel Cancer Screening Programme (BCSP), IDA, symptomatic) and tumour side/stage was assessed using logistic regression models in 1138 CRC cases presenting during 2010–2016 at a single secondary-care centre in the UK. In the IDA sub-group, the relationship between CRC stage and the event of having a blood count prior to CRC diagnosis was examined using Bayesian parametric survival model. IDA was found as the only significant predictor of right-sided CRC (OR 10.61, 95% CI 7.02–16.52). Early-stage CRC was associated with both the IDA (OR 1.65, 95% CI 1.18–2.29) and BCSP pathway (OR 2.42, 95% CI 1.75–3.37). At any age, the risk of detecting CRC at late-stage was higher in those without a previous blood count check (hazard ratio 1.53, 95% credibility interval 1.08–2.14). The findings of this retrospective observational study suggest a benefit from diagnosing CRC through the detection of IDA, and warrant further research into the prognosis benefit of systematic approach to blood count monitoring of the at-risk population.Orouba AlmilajiSally D. ParrySharon DochertyJonathon SnookNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Orouba Almilaji Sally D. Parry Sharon Docherty Jonathon Snook Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia
description	Abstract Iron deficiency anaemia (IDA) is common in colorectal cancer (CRC), especially, in right-sided CRC which is known to have an overall worse prognosis. The associations between diagnostic pathway (Bowel Cancer Screening Programme (BCSP), IDA, symptomatic) and tumour side/stage was assessed using logistic regression models in 1138 CRC cases presenting during 2010–2016 at a single secondary-care centre in the UK. In the IDA sub-group, the relationship between CRC stage and the event of having a blood count prior to CRC diagnosis was examined using Bayesian parametric survival model. IDA was found as the only significant predictor of right-sided CRC (OR 10.61, 95% CI 7.02–16.52). Early-stage CRC was associated with both the IDA (OR 1.65, 95% CI 1.18–2.29) and BCSP pathway (OR 2.42, 95% CI 1.75–3.37). At any age, the risk of detecting CRC at late-stage was higher in those without a previous blood count check (hazard ratio 1.53, 95% credibility interval 1.08–2.14). The findings of this retrospective observational study suggest a benefit from diagnosing CRC through the detection of IDA, and warrant further research into the prognosis benefit of systematic approach to blood count monitoring of the at-risk population.
format	article
author	Orouba Almilaji Sally D. Parry Sharon Docherty Jonathon Snook
author_facet	Orouba Almilaji Sally D. Parry Sharon Docherty Jonathon Snook
author_sort	Orouba Almilaji
title	Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia
title_short	Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia
title_full	Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia
title_fullStr	Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia
title_full_unstemmed	Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia
title_sort	evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d8762b0ad70641a8bc66b69642564f86
work_keys_str_mv	AT oroubaalmilaji evidenceforimprovedprognosisofcolorectalcancerdiagnosedfollowingthedetectionofirondeficiencyanaemia AT sallydparry evidenceforimprovedprognosisofcolorectalcancerdiagnosedfollowingthedetectionofirondeficiencyanaemia AT sharondocherty evidenceforimprovedprognosisofcolorectalcancerdiagnosedfollowingthedetectionofirondeficiencyanaemia AT jonathonsnook evidenceforimprovedprognosisofcolorectalcancerdiagnosedfollowingthedetectionofirondeficiencyanaemia
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Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia

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