Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings

Abstract The imbalance in immune tolerance may cause the variety of reproductive failures. An intravenous immunoglobulin infusion (IVIg) therapy is used to improve the live birth rate in women suffering from recurrent pregnancy loss, recurrent spontaneous abortions and recurrent implantation failure...

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Autores principales:	Anna Ewa Kedzierska, Daria Lorek, Anna Slawek, Anna Chelmonska-Soyta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d8793f69d40d4a03a7f993c1046a0a62
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spelling	oai:doaj.org-article:d8793f69d40d4a03a7f993c1046a0a622021-12-02T16:31:42ZTregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings10.1038/s41598-020-66957-z2045-2322https://doaj.org/article/d8793f69d40d4a03a7f993c1046a0a622020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66957-zhttps://doaj.org/toc/2045-2322Abstract The imbalance in immune tolerance may cause the variety of reproductive failures. An intravenous immunoglobulin infusion (IVIg) therapy is used to improve the live birth rate in women suffering from recurrent pregnancy loss, recurrent spontaneous abortions and recurrent implantation failures. However, the results of IVIg studies are still inconclusive as IVIg infusion in women suffering from pregnancy loss is sometimes ineffective. One of the mechanisms of action of this treatment is inhibition of B cells differentiation and expansion of Tregs and secretion of interleukin 10. It was proposed that immunomodulatory effects of IVIg may be attributed to tregitopes - self-IgG-derived epitopes present in the structure of immunoglobulins. Similarly to IVIg, tregitopes cause the expansion of Tregs and secretion of antigen-specific effector cytokine response. Here, we studied whether the administration of mouse tregitope 167 and/or 289 can prevent abortions in mouse abortion-prone mouse matings. We revealed that tregitopes reduce the foetal death rate. This may be driven by observed higher pool of peripheral Tregs, increased production of IL-10 by Tregs and Bregs and/or maintaining the tolerogenic phenotype of antigen-presenting cells. We believe that our findings may indicate a potential alternative to IVIg for therapeutic intervention in case of pregnancy failures.Anna Ewa KedzierskaDaria LorekAnna SlawekAnna Chelmonska-SoytaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Ewa Kedzierska Daria Lorek Anna Slawek Anna Chelmonska-Soyta Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings
description	Abstract The imbalance in immune tolerance may cause the variety of reproductive failures. An intravenous immunoglobulin infusion (IVIg) therapy is used to improve the live birth rate in women suffering from recurrent pregnancy loss, recurrent spontaneous abortions and recurrent implantation failures. However, the results of IVIg studies are still inconclusive as IVIg infusion in women suffering from pregnancy loss is sometimes ineffective. One of the mechanisms of action of this treatment is inhibition of B cells differentiation and expansion of Tregs and secretion of interleukin 10. It was proposed that immunomodulatory effects of IVIg may be attributed to tregitopes - self-IgG-derived epitopes present in the structure of immunoglobulins. Similarly to IVIg, tregitopes cause the expansion of Tregs and secretion of antigen-specific effector cytokine response. Here, we studied whether the administration of mouse tregitope 167 and/or 289 can prevent abortions in mouse abortion-prone mouse matings. We revealed that tregitopes reduce the foetal death rate. This may be driven by observed higher pool of peripheral Tregs, increased production of IL-10 by Tregs and Bregs and/or maintaining the tolerogenic phenotype of antigen-presenting cells. We believe that our findings may indicate a potential alternative to IVIg for therapeutic intervention in case of pregnancy failures.
format	article
author	Anna Ewa Kedzierska Daria Lorek Anna Slawek Anna Chelmonska-Soyta
author_facet	Anna Ewa Kedzierska Daria Lorek Anna Slawek Anna Chelmonska-Soyta
author_sort	Anna Ewa Kedzierska
title	Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings
title_short	Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings
title_full	Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings
title_fullStr	Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings
title_full_unstemmed	Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings
title_sort	tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d8793f69d40d4a03a7f993c1046a0a62
work_keys_str_mv	AT annaewakedzierska tregitopesregulatethetolerogenicimmuneresponseanddecreasethefoetaldeathrateinabortionpronemousematings AT darialorek tregitopesregulatethetolerogenicimmuneresponseanddecreasethefoetaldeathrateinabortionpronemousematings AT annaslawek tregitopesregulatethetolerogenicimmuneresponseanddecreasethefoetaldeathrateinabortionpronemousematings AT annachelmonskasoyta tregitopesregulatethetolerogenicimmuneresponseanddecreasethefoetaldeathrateinabortionpronemousematings
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Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings

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