The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis

Abstract Molar-Incisor Hypomineralization (MIH) is a qualitative defect of enamel of unknown etiology, affecting one or more permanent molars and may include incisors. This condition is a clinical challenge and its prevalence is still uncertain given the recent increase in research. Thus, we aimed t...

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Autores principales:	Luísa Bandeira Lopes, Vanessa Machado, Paulo Mascarenhas, José João Mendes, João Botelho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d87aa77aae3c4452a661f2128c3d568d
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spelling	oai:doaj.org-article:d87aa77aae3c4452a661f2128c3d568d2021-11-21T12:19:50ZThe prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis10.1038/s41598-021-01541-72045-2322https://doaj.org/article/d87aa77aae3c4452a661f2128c3d568d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01541-7https://doaj.org/toc/2045-2322Abstract Molar-Incisor Hypomineralization (MIH) is a qualitative defect of enamel of unknown etiology, affecting one or more permanent molars and may include incisors. This condition is a clinical challenge and its prevalence is still uncertain given the recent increase in research. Thus, we aimed to comprehensively estimate the overall prevalence of MIH and associated characteristics. This systematic review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). We searched articles using PubMed, MEDLINE, CENTRAL, Web of Science, SciELO, LILACS and TRIP databases, until July 2021. Heterogeneity and publication bias were computed via I2 test statistics and Egger’s significance test, respectively. Random-effects meta-analysis of prevalence were processed. We used the Strength of Recommendation Taxonomy [SORT] to grading the strength of evidence. Overall, 116 observational studies were included, with one study with moderate methodological quality and the remaining of high methodological quality. Subgroup analysis confirmed an influence of not using the 2003 MIH case definition (p = 0.0066). The pooled prevalence of MIH was 13.5% (95% CI 12.0–15.1, I2 = 98.0%). Affected incisors were seen in 36.6% (95% CI 30.0–43.7, I2 = 92.5%) of the cases. Lastly, the prevalence of hypomineralization of the second primary molars was observed in 3.6% of the MIH cases (95% CI 1.9–6.8, I2 = 96.3%). America was the continent with highest prevalence (15.3, 95% CI 12.8–18.3, p < 0.001, I2 = 96.3%) and Asia had the lowest prevalence (10.7, 95% CI 8.5–13.5, p < 0.001, I2 = 98.7%), however no continental differences were found. Sample size and year of publication were slight contributing factors to the heterogeneity in the analysis. Overall, these results were classified with a SORT A recommendation.Luísa Bandeira LopesVanessa MachadoPaulo MascarenhasJosé João MendesJoão BotelhoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luísa Bandeira Lopes Vanessa Machado Paulo Mascarenhas José João Mendes João Botelho The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis
description	Abstract Molar-Incisor Hypomineralization (MIH) is a qualitative defect of enamel of unknown etiology, affecting one or more permanent molars and may include incisors. This condition is a clinical challenge and its prevalence is still uncertain given the recent increase in research. Thus, we aimed to comprehensively estimate the overall prevalence of MIH and associated characteristics. This systematic review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). We searched articles using PubMed, MEDLINE, CENTRAL, Web of Science, SciELO, LILACS and TRIP databases, until July 2021. Heterogeneity and publication bias were computed via I2 test statistics and Egger’s significance test, respectively. Random-effects meta-analysis of prevalence were processed. We used the Strength of Recommendation Taxonomy [SORT] to grading the strength of evidence. Overall, 116 observational studies were included, with one study with moderate methodological quality and the remaining of high methodological quality. Subgroup analysis confirmed an influence of not using the 2003 MIH case definition (p = 0.0066). The pooled prevalence of MIH was 13.5% (95% CI 12.0–15.1, I2 = 98.0%). Affected incisors were seen in 36.6% (95% CI 30.0–43.7, I2 = 92.5%) of the cases. Lastly, the prevalence of hypomineralization of the second primary molars was observed in 3.6% of the MIH cases (95% CI 1.9–6.8, I2 = 96.3%). America was the continent with highest prevalence (15.3, 95% CI 12.8–18.3, p < 0.001, I2 = 96.3%) and Asia had the lowest prevalence (10.7, 95% CI 8.5–13.5, p < 0.001, I2 = 98.7%), however no continental differences were found. Sample size and year of publication were slight contributing factors to the heterogeneity in the analysis. Overall, these results were classified with a SORT A recommendation.
format	article
author	Luísa Bandeira Lopes Vanessa Machado Paulo Mascarenhas José João Mendes João Botelho
author_facet	Luísa Bandeira Lopes Vanessa Machado Paulo Mascarenhas José João Mendes João Botelho
author_sort	Luísa Bandeira Lopes
title	The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis
title_short	The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis
title_full	The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis
title_fullStr	The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis
title_full_unstemmed	The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis
title_sort	prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d87aa77aae3c4452a661f2128c3d568d
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The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis

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