Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.

<h4>Background and purpose</h4>Coagulation factor XI (FXI) has an important role in the propagation and stabilization of a thrombus upon vessel injury. High FXI levels have been implicated in thrombotic diseases including ischemic stroke. The aim of our study was to investigate whether F...

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Autores principales:	Ellen Hanson, Staffan Nilsson, Katarina Jood, Bo Norrving, Gunnar Engström, Christian Blomstrand, Arne Lindgren, Olle Melander, Christina Jern
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d87bba6ce46644319a3f589fdd233708
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spelling	oai:doaj.org-article:d87bba6ce46644319a3f589fdd2337082021-11-18T08:53:47ZGenetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.1932-620310.1371/journal.pone.0075286https://doaj.org/article/d87bba6ce46644319a3f589fdd2337082013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086496/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and purpose</h4>Coagulation factor XI (FXI) has an important role in the propagation and stabilization of a thrombus upon vessel injury. High FXI levels have been implicated in thrombotic diseases including ischemic stroke. The aim of our study was to investigate whether FXI gene (F11) variants are associated with ischemic stroke.<h4>Methods</h4>The discovery sample, the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), included 844 patients with ischemic stroke and 668 controls, all aged 18-70 years. Replication was performed in the Lund Stroke Register (LSR) and Malmö Diet and Cancer study (MDC), together including 1213 patients and 788 controls up to 70 years of age, and in total 3145 patients and 1793 controls (18-102 years). Seven F11 single-nucleotide polymorphisms (SNPs) were selected using a tagging approach.<h4>Results</h4>The SNPs rs3733403, rs925451, and rs1593 showed independent associations with overall ischemic stroke in SAHLSIS, ORs of 0.74 (95% CI 0.59-0.94), 1.24 (95% CI 1.06-1.46), and 0.70 (95% CI 0.55-0.90), respectively. The association for rs925451 was replicated in the LSR and MDC sample in a pre-specified analysis of subjects aged 70 years or younger, OR of 1.16 (95% CI 1.00-1.34), whereas no SNP was replicated when all ages were included. In line with this, one F11 haplotype was associated with overall ischemic stroke in the discovery sample and in the replication sample ≤70 years.<h4>Conclusions</h4>We found significant associations between F11 variation and overall ischemic stroke up to 70 years of age. These findings motivate further studies on the role of F11 in ischemic stroke, especially in younger individuals.Ellen HansonStaffan NilssonKatarina JoodBo NorrvingGunnar EngströmChristian BlomstrandArne LindgrenOlle MelanderChristina JernPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75286 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ellen Hanson Staffan Nilsson Katarina Jood Bo Norrving Gunnar Engström Christian Blomstrand Arne Lindgren Olle Melander Christina Jern Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.
description	<h4>Background and purpose</h4>Coagulation factor XI (FXI) has an important role in the propagation and stabilization of a thrombus upon vessel injury. High FXI levels have been implicated in thrombotic diseases including ischemic stroke. The aim of our study was to investigate whether FXI gene (F11) variants are associated with ischemic stroke.<h4>Methods</h4>The discovery sample, the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), included 844 patients with ischemic stroke and 668 controls, all aged 18-70 years. Replication was performed in the Lund Stroke Register (LSR) and Malmö Diet and Cancer study (MDC), together including 1213 patients and 788 controls up to 70 years of age, and in total 3145 patients and 1793 controls (18-102 years). Seven F11 single-nucleotide polymorphisms (SNPs) were selected using a tagging approach.<h4>Results</h4>The SNPs rs3733403, rs925451, and rs1593 showed independent associations with overall ischemic stroke in SAHLSIS, ORs of 0.74 (95% CI 0.59-0.94), 1.24 (95% CI 1.06-1.46), and 0.70 (95% CI 0.55-0.90), respectively. The association for rs925451 was replicated in the LSR and MDC sample in a pre-specified analysis of subjects aged 70 years or younger, OR of 1.16 (95% CI 1.00-1.34), whereas no SNP was replicated when all ages were included. In line with this, one F11 haplotype was associated with overall ischemic stroke in the discovery sample and in the replication sample ≤70 years.<h4>Conclusions</h4>We found significant associations between F11 variation and overall ischemic stroke up to 70 years of age. These findings motivate further studies on the role of F11 in ischemic stroke, especially in younger individuals.
format	article
author	Ellen Hanson Staffan Nilsson Katarina Jood Bo Norrving Gunnar Engström Christian Blomstrand Arne Lindgren Olle Melander Christina Jern
author_facet	Ellen Hanson Staffan Nilsson Katarina Jood Bo Norrving Gunnar Engström Christian Blomstrand Arne Lindgren Olle Melander Christina Jern
author_sort	Ellen Hanson
title	Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.
title_short	Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.
title_full	Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.
title_fullStr	Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.
title_full_unstemmed	Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.
title_sort	genetic variants of coagulation factor xi show association with ischemic stroke up to 70 years of age.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d87bba6ce46644319a3f589fdd233708
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Genetic variants of coagulation factor XI show association with ischemic stroke up to 70 years of age.

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