Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study

Abstract Background Zinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are reduced by the administration of zinc, we retrospectively investigated...

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Autores principales:	Toshikazu Ito, Kazuya Uenoyama, Kazuhiro Kobayashi, Mikio Kakumoto, Hiroshi Mizumoto, Toshiya Katsura, Masahide Onoue
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Preterm infants Zinc Copper Serum concentration Hypozincemia Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d87def1ce92445f8aa693e5630b0d583
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spelling	oai:doaj.org-article:d87def1ce92445f8aa693e5630b0d5832021-12-05T12:03:12ZAdministration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study10.1186/s40780-021-00229-42055-0294https://doaj.org/article/d87def1ce92445f8aa693e5630b0d5832021-12-01T00:00:00Zhttps://doi.org/10.1186/s40780-021-00229-4https://doaj.org/toc/2055-0294Abstract Background Zinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are reduced by the administration of zinc, we retrospectively investigated changes in serum zinc and copper concentrations in preterm infants with hypozincemia receiving zinc acetate dihydrate. Methods Sixty-three preterm infants were included in the present study. Serum zinc and copper concentrations, doses, and other clinical characteristics were retrieved from electronic medical records. Results The medians and interquartile ranges of the dosage and duration of zinc acetate dihydrate were 2.1 (1.8–2.5) mg/kg/day and 12.0 (10.0–13.0) days, respectively. Its administration increased serum zinc concentrations in 39 patients (61.9%) and to more than 70 μg/dL in 16 patients (25.4%). The group with a serum zinc concentration of 70 μg/dL or higher after administration had a significantly higher zinc dose of 2.5 mg/kg/day than the group with a serum zinc concentration of less than 70 μg/dL. Serum copper concentrations did not decrease in 44 patients (69.8%). In the group with a decreased serum copper concentration, postmenstrual age and body weight were significantly lower, while serum zinc concentrations were significantly higher at the start of administration. Conclusion The present results showed that when zinc acetate dihydrate was administered to preterm infants with hypozincemia, it was possible to increase serum zinc concentrations without decreasing serum copper concentrations in many cases. However, caution may be required when administering zinc to preterm infants with a lower postmenstrual age or milder hypozincemia because serum copper concentrations may decrease.Toshikazu ItoKazuya UenoyamaKazuhiro KobayashiMikio KakumotoHiroshi MizumotoToshiya KatsuraMasahide OnoueBMCarticlePreterm infantsZincCopperSerum concentrationHypozincemiaTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Pharmaceutical Health Care and Sciences, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Preterm infants Zinc Copper Serum concentration Hypozincemia Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	Preterm infants Zinc Copper Serum concentration Hypozincemia Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Toshikazu Ito Kazuya Uenoyama Kazuhiro Kobayashi Mikio Kakumoto Hiroshi Mizumoto Toshiya Katsura Masahide Onoue Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study
description	Abstract Background Zinc is an essential trace element involved in various physiological functions. In Japan, zinc acetate dihydrate is administered to neonates and infants with hypozincemia. Since serum copper concentrations are reduced by the administration of zinc, we retrospectively investigated changes in serum zinc and copper concentrations in preterm infants with hypozincemia receiving zinc acetate dihydrate. Methods Sixty-three preterm infants were included in the present study. Serum zinc and copper concentrations, doses, and other clinical characteristics were retrieved from electronic medical records. Results The medians and interquartile ranges of the dosage and duration of zinc acetate dihydrate were 2.1 (1.8–2.5) mg/kg/day and 12.0 (10.0–13.0) days, respectively. Its administration increased serum zinc concentrations in 39 patients (61.9%) and to more than 70 μg/dL in 16 patients (25.4%). The group with a serum zinc concentration of 70 μg/dL or higher after administration had a significantly higher zinc dose of 2.5 mg/kg/day than the group with a serum zinc concentration of less than 70 μg/dL. Serum copper concentrations did not decrease in 44 patients (69.8%). In the group with a decreased serum copper concentration, postmenstrual age and body weight were significantly lower, while serum zinc concentrations were significantly higher at the start of administration. Conclusion The present results showed that when zinc acetate dihydrate was administered to preterm infants with hypozincemia, it was possible to increase serum zinc concentrations without decreasing serum copper concentrations in many cases. However, caution may be required when administering zinc to preterm infants with a lower postmenstrual age or milder hypozincemia because serum copper concentrations may decrease.
format	article
author	Toshikazu Ito Kazuya Uenoyama Kazuhiro Kobayashi Mikio Kakumoto Hiroshi Mizumoto Toshiya Katsura Masahide Onoue
author_facet	Toshikazu Ito Kazuya Uenoyama Kazuhiro Kobayashi Mikio Kakumoto Hiroshi Mizumoto Toshiya Katsura Masahide Onoue
author_sort	Toshikazu Ito
title	Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study
title_short	Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study
title_full	Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study
title_fullStr	Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study
title_full_unstemmed	Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study
title_sort	administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d87def1ce92445f8aa693e5630b0d583
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Administration of zinc to preterm infants with hypozincemia does not reduce serum copper concentrations in most cases: a single-center retrospective observational study

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