Practical combination therapy based on pathophysiology of type 2 diabetes

Philip A Levin MODEL Clinical Research, Endocrinology, Department of Medicine, Greater Baltimore Medical Center, Baltimore, MD, USA Abstract: Type 2 diabetes is a complex, chronic, and progressive condition that often necessitates the use of multiple medications to achieve glycemic goals. Clinical g...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Levin PA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Type 2 diabetes combination therapy oral antidiabetes drugs insulin Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d880000e07b84ec485688e6ac7a94a15
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d880000e07b84ec485688e6ac7a94a15
record_format	dspace
spelling	oai:doaj.org-article:d880000e07b84ec485688e6ac7a94a152021-12-02T07:53:25ZPractical combination therapy based on pathophysiology of type 2 diabetes1178-7007https://doaj.org/article/d880000e07b84ec485688e6ac7a94a152016-10-01T00:00:00Zhttps://www.dovepress.com/practical-combination-therapy-based-on-pathophysiology-of-type-2-diabe-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Philip A Levin MODEL Clinical Research, Endocrinology, Department of Medicine, Greater Baltimore Medical Center, Baltimore, MD, USA Abstract: Type 2 diabetes is a complex, chronic, and progressive condition that often necessitates the use of multiple medications to achieve glycemic goals. Clinical guidelines generally recommend intensifying pharmacotherapy if glycemic goals are not achieved after 3 months of treatment. However, for many patients with type 2 diabetes, treatment intensification is delayed or does not occur. Initiating combination therapy early in the disease course has the potential to delay disease progression and improve patient outcomes. Guidelines generally provide a list of agents that may be used in combination regimens and emphasize individualization of treatment. The purpose of this review is to discuss the rationale for combination therapy, considering treatment effects on pathophysiologic aspects of type 2 diabetes and individual drug profiles. The combination of newer antidiabetes therapies with complementary mechanisms of action provides the opportunity to target multiple sites of tissue, organ, and cellular dysfunction. Keywords: type 2 diabetes, combination therapy, oral antidiabetes drugs, insulinLevin PADove Medical PressarticleType 2 diabetescombination therapyoral antidiabetes drugsinsulinSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 9, Pp 355-369 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes combination therapy oral antidiabetes drugs insulin Specialties of internal medicine RC581-951
spellingShingle	Type 2 diabetes combination therapy oral antidiabetes drugs insulin Specialties of internal medicine RC581-951 Levin PA Practical combination therapy based on pathophysiology of type 2 diabetes
description	Philip A Levin MODEL Clinical Research, Endocrinology, Department of Medicine, Greater Baltimore Medical Center, Baltimore, MD, USA Abstract: Type 2 diabetes is a complex, chronic, and progressive condition that often necessitates the use of multiple medications to achieve glycemic goals. Clinical guidelines generally recommend intensifying pharmacotherapy if glycemic goals are not achieved after 3 months of treatment. However, for many patients with type 2 diabetes, treatment intensification is delayed or does not occur. Initiating combination therapy early in the disease course has the potential to delay disease progression and improve patient outcomes. Guidelines generally provide a list of agents that may be used in combination regimens and emphasize individualization of treatment. The purpose of this review is to discuss the rationale for combination therapy, considering treatment effects on pathophysiologic aspects of type 2 diabetes and individual drug profiles. The combination of newer antidiabetes therapies with complementary mechanisms of action provides the opportunity to target multiple sites of tissue, organ, and cellular dysfunction. Keywords: type 2 diabetes, combination therapy, oral antidiabetes drugs, insulin
format	article
author	Levin PA
author_facet	Levin PA
author_sort	Levin PA
title	Practical combination therapy based on pathophysiology of type 2 diabetes
title_short	Practical combination therapy based on pathophysiology of type 2 diabetes
title_full	Practical combination therapy based on pathophysiology of type 2 diabetes
title_fullStr	Practical combination therapy based on pathophysiology of type 2 diabetes
title_full_unstemmed	Practical combination therapy based on pathophysiology of type 2 diabetes
title_sort	practical combination therapy based on pathophysiology of type 2 diabetes
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d880000e07b84ec485688e6ac7a94a15
work_keys_str_mv	AT levinpa practicalcombinationtherapybasedonpathophysiologyoftype2diabetes
_version_	1718399131897036800

Practical combination therapy based on pathophysiology of type 2 diabetes

Ejemplares similares