Anti-inflammatory effect of gold nanoparticles supported on metal oxides

Abstract Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takashi Fujita, Maeva Zysman, Dan Elgrabli, Toru Murayama, Masatake Haruta, Sophie Lanone, Tamao Ishida, Jorge Boczkowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d88168994f274626b60d9f985c2624b7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d88168994f274626b60d9f985c2624b7
record_format	dspace
spelling	oai:doaj.org-article:d88168994f274626b60d9f985c2624b72021-12-05T12:15:27ZAnti-inflammatory effect of gold nanoparticles supported on metal oxides10.1038/s41598-021-02419-42045-2322https://doaj.org/article/d88168994f274626b60d9f985c2624b72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02419-4https://doaj.org/toc/2045-2322Abstract Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation of the inflammatory reaction. Therefore, the aim of this study was to examine the effect of Au/TiO2, Au/ZrO2 and Au/CeO2 on viability, phagocytic capacity and inflammatory profile (TNF-α and IL-1β secretion) of murine macrophages. The most important result of this study is an anti-inflammatory effect of Au/MOx depending on the MOx nature with particle internalization and no alteration of cell viability and phagocytosis. The effect was dependent on the MOx NPs chemical nature (Au/TiO2 > Au/ZrO2 > Au/CeO2 if we consider the number of cytokines whose concentration was reduced by the NPs), and on the inflammatory mediator considered. The effect of Au/TiO2 NPs was not related to Au NPs size (at least in the case of Au/TiO2 NPs in the range of 3–8 nm). To the best of our knowledge, this is the first demonstration of an anti-inflammatory effect of Au/MOx.Takashi FujitaMaeva ZysmanDan ElgrabliToru MurayamaMasatake HarutaSophie LanoneTamao IshidaJorge BoczkowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takashi Fujita Maeva Zysman Dan Elgrabli Toru Murayama Masatake Haruta Sophie Lanone Tamao Ishida Jorge Boczkowski Anti-inflammatory effect of gold nanoparticles supported on metal oxides
description	Abstract Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation of the inflammatory reaction. Therefore, the aim of this study was to examine the effect of Au/TiO2, Au/ZrO2 and Au/CeO2 on viability, phagocytic capacity and inflammatory profile (TNF-α and IL-1β secretion) of murine macrophages. The most important result of this study is an anti-inflammatory effect of Au/MOx depending on the MOx nature with particle internalization and no alteration of cell viability and phagocytosis. The effect was dependent on the MOx NPs chemical nature (Au/TiO2 > Au/ZrO2 > Au/CeO2 if we consider the number of cytokines whose concentration was reduced by the NPs), and on the inflammatory mediator considered. The effect of Au/TiO2 NPs was not related to Au NPs size (at least in the case of Au/TiO2 NPs in the range of 3–8 nm). To the best of our knowledge, this is the first demonstration of an anti-inflammatory effect of Au/MOx.
format	article
author	Takashi Fujita Maeva Zysman Dan Elgrabli Toru Murayama Masatake Haruta Sophie Lanone Tamao Ishida Jorge Boczkowski
author_facet	Takashi Fujita Maeva Zysman Dan Elgrabli Toru Murayama Masatake Haruta Sophie Lanone Tamao Ishida Jorge Boczkowski
author_sort	Takashi Fujita
title	Anti-inflammatory effect of gold nanoparticles supported on metal oxides
title_short	Anti-inflammatory effect of gold nanoparticles supported on metal oxides
title_full	Anti-inflammatory effect of gold nanoparticles supported on metal oxides
title_fullStr	Anti-inflammatory effect of gold nanoparticles supported on metal oxides
title_full_unstemmed	Anti-inflammatory effect of gold nanoparticles supported on metal oxides
title_sort	anti-inflammatory effect of gold nanoparticles supported on metal oxides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d88168994f274626b60d9f985c2624b7
work_keys_str_mv	AT takashifujita antiinflammatoryeffectofgoldnanoparticlessupportedonmetaloxides AT maevazysman antiinflammatoryeffectofgoldnanoparticlessupportedonmetaloxides AT danelgrabli antiinflammatoryeffectofgoldnanoparticlessupportedonmetaloxides AT torumurayama antiinflammatoryeffectofgoldnanoparticlessupportedonmetaloxides AT masatakeharuta antiinflammatoryeffectofgoldnanoparticlessupportedonmetaloxides AT sophielanone antiinflammatoryeffectofgoldnanoparticlessupportedonmetaloxides AT tamaoishida antiinflammatoryeffectofgoldnanoparticlessupportedonmetaloxides AT jorgeboczkowski antiinflammatoryeffectofgoldnanoparticlessupportedonmetaloxides
_version_	1718372106492706816

Anti-inflammatory effect of gold nanoparticles supported on metal oxides

Ejemplares similares