The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.

Guardado en:

Detalles Bibliográficos
Autores principales:	Woelsung Yi, Sanjay Gupta, Edd Ricker, Michela Manni, Rolf Jessberger, Yurii Chinenov, Henrik Molina, Alessandra B. Pernis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8898e9c90074000ad87e4d3b1cd931c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d8898e9c90074000ad87e4d3b1cd931c
record_format	dspace
spelling	oai:doaj.org-article:d8898e9c90074000ad87e4d3b1cd931c2021-12-02T13:23:47ZThe mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity10.1038/s41467-017-00348-32041-1723https://doaj.org/article/d8898e9c90074000ad87e4d3b1cd931c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00348-3https://doaj.org/toc/2041-1723Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.Woelsung YiSanjay GuptaEdd RickerMichela ManniRolf JessbergerYurii ChinenovHenrik MolinaAlessandra B. PernisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Woelsung Yi Sanjay Gupta Edd Ricker Michela Manni Rolf Jessberger Yurii Chinenov Henrik Molina Alessandra B. Pernis The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
description	Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.
format	article
author	Woelsung Yi Sanjay Gupta Edd Ricker Michela Manni Rolf Jessberger Yurii Chinenov Henrik Molina Alessandra B. Pernis
author_facet	Woelsung Yi Sanjay Gupta Edd Ricker Michela Manni Rolf Jessberger Yurii Chinenov Henrik Molina Alessandra B. Pernis
author_sort	Woelsung Yi
title	The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
title_short	The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
title_full	The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
title_fullStr	The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
title_full_unstemmed	The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
title_sort	mtorc1-4e-bp-eif4e axis controls de novo bcl6 protein synthesis in t cells and systemic autoimmunity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d8898e9c90074000ad87e4d3b1cd931c
work_keys_str_mv	AT woelsungyi themtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT sanjaygupta themtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT eddricker themtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT michelamanni themtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT rolfjessberger themtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT yuriichinenov themtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT henrikmolina themtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT alessandrabpernis themtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT woelsungyi mtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT sanjaygupta mtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT eddricker mtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT michelamanni mtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT rolfjessberger mtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT yuriichinenov mtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT henrikmolina mtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity AT alessandrabpernis mtorc14ebpeif4eaxiscontrolsdenovobcl6proteinsynthesisintcellsandsystemicautoimmunity
_version_	1718393182939512832

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

Ejemplares similares