Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis

Abstract Leaves of Cyclocarya paliurus are a sweet tea traditionally used to treat obesity and diabetes in China. However, its protective mechanisms against hyperglycemia remains unclear. Here, we demonstrate that the extract of C. paliurus leaves significantly decreased body loss, food intake and b...

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Autores principales:	Hai-tao Xiao, Bo Wen, Zi-wan Ning, Li-xiang Zhai, Cheng-hui Liao, Cheng-yuan Lin, Huai-xue Mu, Zhao-xiang Bian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d88a452633354c1b98c7902dbe859eac
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spelling	oai:doaj.org-article:d88a452633354c1b98c7902dbe859eac2021-12-02T16:06:12ZCyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis10.1038/s41598-017-09641-z2045-2322https://doaj.org/article/d88a452633354c1b98c7902dbe859eac2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09641-zhttps://doaj.org/toc/2045-2322Abstract Leaves of Cyclocarya paliurus are a sweet tea traditionally used to treat obesity and diabetes in China. However, its protective mechanisms against hyperglycemia remains unclear. Here, we demonstrate that the extract of C. paliurus leaves significantly decreased body loss, food intake and blood glucose level, and increased blood insulin level, β-cell number and insulin-producing β cells in high-fat diet-low dose STZ-induced diabetic mice. In vivo and in vitro studies also showed the extract of C. paliurus leaves significantly inhibited pancreatic β cell apoptosis by suppressing the expression of caspase 8, caspase 9 and cleaved caspase-3, as well as Bax/Bcl-2 ratio, down-regulating p38, ERK and JNK phosphorylation, and up-regulating Akt phosphorylation. These effects were significantly enhanced by inhibitor p-38 or ERK or JNK, and counteracted by inhibitor of PI3K. In addition, the extract of C. paliurus leaves also significantly improved hepatic steatosis, nephropathy and cardiac hypertrophy of diabetic mice. Taken together, these results provide the insight into the effects of C. paliurus leaves on pancreatic β cell preservation in standing glucolipotoxicity. Therefore, C. paliurus tea leaves may be used as a new remedy for diabetes through enhancing pancreatic β cell preservation by inhibiting β cell apoptosis.Hai-tao XiaoBo WenZi-wan NingLi-xiang ZhaiCheng-hui LiaoCheng-yuan LinHuai-xue MuZhao-xiang BianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hai-tao Xiao Bo Wen Zi-wan Ning Li-xiang Zhai Cheng-hui Liao Cheng-yuan Lin Huai-xue Mu Zhao-xiang Bian Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis
description	Abstract Leaves of Cyclocarya paliurus are a sweet tea traditionally used to treat obesity and diabetes in China. However, its protective mechanisms against hyperglycemia remains unclear. Here, we demonstrate that the extract of C. paliurus leaves significantly decreased body loss, food intake and blood glucose level, and increased blood insulin level, β-cell number and insulin-producing β cells in high-fat diet-low dose STZ-induced diabetic mice. In vivo and in vitro studies also showed the extract of C. paliurus leaves significantly inhibited pancreatic β cell apoptosis by suppressing the expression of caspase 8, caspase 9 and cleaved caspase-3, as well as Bax/Bcl-2 ratio, down-regulating p38, ERK and JNK phosphorylation, and up-regulating Akt phosphorylation. These effects were significantly enhanced by inhibitor p-38 or ERK or JNK, and counteracted by inhibitor of PI3K. In addition, the extract of C. paliurus leaves also significantly improved hepatic steatosis, nephropathy and cardiac hypertrophy of diabetic mice. Taken together, these results provide the insight into the effects of C. paliurus leaves on pancreatic β cell preservation in standing glucolipotoxicity. Therefore, C. paliurus tea leaves may be used as a new remedy for diabetes through enhancing pancreatic β cell preservation by inhibiting β cell apoptosis.
format	article
author	Hai-tao Xiao Bo Wen Zi-wan Ning Li-xiang Zhai Cheng-hui Liao Cheng-yuan Lin Huai-xue Mu Zhao-xiang Bian
author_facet	Hai-tao Xiao Bo Wen Zi-wan Ning Li-xiang Zhai Cheng-hui Liao Cheng-yuan Lin Huai-xue Mu Zhao-xiang Bian
author_sort	Hai-tao Xiao
title	Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis
title_short	Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis
title_full	Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis
title_fullStr	Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis
title_full_unstemmed	Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis
title_sort	cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d88a452633354c1b98c7902dbe859eac
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Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis

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