DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.

<h4>Background</h4>The effect of referring patients from a clinical setting to a pragmatic exercise intervention for depressive symptoms, cognitive function, and metabolic variables has yet to be determined.<h4>Methods</h4>Outpatients with major depression (DSM-IV) were alloc...

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Autores principales:	Jesper Krogh, Poul Videbech, Carsten Thomsen, Christian Gluud, Merete Nordentoft
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d88a9074064b4f2985cd2eee42c358d2
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spelling	oai:doaj.org-article:d88a9074064b4f2985cd2eee42c358d22021-11-18T08:10:26ZDEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.1932-620310.1371/journal.pone.0048316https://doaj.org/article/d88a9074064b4f2985cd2eee42c358d22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23118981/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The effect of referring patients from a clinical setting to a pragmatic exercise intervention for depressive symptoms, cognitive function, and metabolic variables has yet to be determined.<h4>Methods</h4>Outpatients with major depression (DSM-IV) were allocated to supervised aerobic or stretching exercise groups during a three months period. The primary outcome was the Hamilton depression score (HAM-D(17)). Secondary outcomes were cognitive function, cardiovascular risk markers, and employment related outcomes.<h4>Results</h4>56 participants were allocated to the aerobic exercise intervention versus 59 participants to the stretching exercise group. Post intervention the mean difference between groups was -0.78 points on the HAM-D(17) (95% CI -3.2 to 1.6; P = .52). At follow-up, the participants in the aerobic exercise group had higher maximal oxygen uptake (mean difference 4.4 l/kg/min; 95% CI 1.7 to 7.0; P = .001) and visuospatial memory on Rey's Complex Figure Test (mean difference 3.2 points; 95% CI 0.9 to 5.5; P = .007) and lower blood glucose levels (mean difference 0.2 mmol/l; 95% CI 0.0 to 0.5; P = .04) and waist circumference (mean difference 2.2 cm; 95% CI 0.3 to 4.1; P = .02) compared with the stretching exercise group.<h4>Conclusions</h4>The results of this trial does not support any antidepressant effect of referring patients with major depression to a three months aerobic exercise program. Due to lower recruitment than anticipated, the trial was terminated prior to reaching the pre-defined sample size of 212 participants; therefore the results should be interpreted in that context. However, the DEMO-II trial does suggest that an exercise program for patients with depression offer positive short-term effects on maximal oxygen uptake, visuospatial memory, fasting glucose levels, and waist circumference.<h4>Trial registration</h4>ClinicalTrials.gov NCT00695552.Jesper KroghPoul VidebechCarsten ThomsenChristian GluudMerete NordentoftPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e48316 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jesper Krogh Poul Videbech Carsten Thomsen Christian Gluud Merete Nordentoft DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.
description	<h4>Background</h4>The effect of referring patients from a clinical setting to a pragmatic exercise intervention for depressive symptoms, cognitive function, and metabolic variables has yet to be determined.<h4>Methods</h4>Outpatients with major depression (DSM-IV) were allocated to supervised aerobic or stretching exercise groups during a three months period. The primary outcome was the Hamilton depression score (HAM-D(17)). Secondary outcomes were cognitive function, cardiovascular risk markers, and employment related outcomes.<h4>Results</h4>56 participants were allocated to the aerobic exercise intervention versus 59 participants to the stretching exercise group. Post intervention the mean difference between groups was -0.78 points on the HAM-D(17) (95% CI -3.2 to 1.6; P = .52). At follow-up, the participants in the aerobic exercise group had higher maximal oxygen uptake (mean difference 4.4 l/kg/min; 95% CI 1.7 to 7.0; P = .001) and visuospatial memory on Rey's Complex Figure Test (mean difference 3.2 points; 95% CI 0.9 to 5.5; P = .007) and lower blood glucose levels (mean difference 0.2 mmol/l; 95% CI 0.0 to 0.5; P = .04) and waist circumference (mean difference 2.2 cm; 95% CI 0.3 to 4.1; P = .02) compared with the stretching exercise group.<h4>Conclusions</h4>The results of this trial does not support any antidepressant effect of referring patients with major depression to a three months aerobic exercise program. Due to lower recruitment than anticipated, the trial was terminated prior to reaching the pre-defined sample size of 212 participants; therefore the results should be interpreted in that context. However, the DEMO-II trial does suggest that an exercise program for patients with depression offer positive short-term effects on maximal oxygen uptake, visuospatial memory, fasting glucose levels, and waist circumference.<h4>Trial registration</h4>ClinicalTrials.gov NCT00695552.
format	article
author	Jesper Krogh Poul Videbech Carsten Thomsen Christian Gluud Merete Nordentoft
author_facet	Jesper Krogh Poul Videbech Carsten Thomsen Christian Gluud Merete Nordentoft
author_sort	Jesper Krogh
title	DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.
title_short	DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.
title_full	DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.
title_fullStr	DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.
title_full_unstemmed	DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.
title_sort	demo-ii trial. aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d88a9074064b4f2985cd2eee42c358d2
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DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial.

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