Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer

The Chinese medicine monomer cynaroside (Cy) is a flavonoid glycoside compound that widely exists in plants and has a variety of pharmacological effects, such as its important role in the respiratory system, cardiovascular system and central nervous system. Studies have reported that Cy has varying...

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Autores principales:	Juanli Ji, Zhongze Wang, Wei Sun, Zekun Li, Huarui Cai, Erhu Zhao, Hongjuan Cui
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gastric cancer cynaroside cell proliferation migration and invasion MET Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d896f5b362034d1abded7a55b9708b0e
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spelling	oai:doaj.org-article:d896f5b362034d1abded7a55b9708b0e2021-11-25T17:53:39ZEffects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer10.3390/ijms2222121251422-00671661-6596https://doaj.org/article/d896f5b362034d1abded7a55b9708b0e2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12125https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The Chinese medicine monomer cynaroside (Cy) is a flavonoid glycoside compound that widely exists in plants and has a variety of pharmacological effects, such as its important role in the respiratory system, cardiovascular system and central nervous system. Studies have reported that Cy has varying degrees of anticancer activity in non-small cell lung cancer, cervical cancer, liver cancer, esophageal cancer and other cancers. However, there are no relevant reports about its role in gastric cancer. The MET/AKT/mTOR signaling pathway plays important roles in regulating various biological processes, including cell proliferation, apoptosis, autophagy, invasion and tumorigenesis. In this study, we confirmed that Cy can inhibit the cell growth, migration and invasion and tumorigenesis in gastric cancer. Our finding shows that Cy can block the MET/AKT/mTOR axis by decreasing the phosphorylation level of AKT, mTOR and P70S6K. Therefore, the MET/AKT/mTOR axis may be an important target for Cy. In summary, Cy has anti-cancer properties and is expected to be a potential drug for the treatment of gastric cancer.Juanli JiZhongze WangWei SunZekun LiHuarui CaiErhu ZhaoHongjuan CuiMDPI AGarticlegastric cancercynarosidecell proliferationmigration and invasionMETBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12125, p 12125 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer cynaroside cell proliferation migration and invasion MET Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	gastric cancer cynaroside cell proliferation migration and invasion MET Biology (General) QH301-705.5 Chemistry QD1-999 Juanli Ji Zhongze Wang Wei Sun Zekun Li Huarui Cai Erhu Zhao Hongjuan Cui Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer
description	The Chinese medicine monomer cynaroside (Cy) is a flavonoid glycoside compound that widely exists in plants and has a variety of pharmacological effects, such as its important role in the respiratory system, cardiovascular system and central nervous system. Studies have reported that Cy has varying degrees of anticancer activity in non-small cell lung cancer, cervical cancer, liver cancer, esophageal cancer and other cancers. However, there are no relevant reports about its role in gastric cancer. The MET/AKT/mTOR signaling pathway plays important roles in regulating various biological processes, including cell proliferation, apoptosis, autophagy, invasion and tumorigenesis. In this study, we confirmed that Cy can inhibit the cell growth, migration and invasion and tumorigenesis in gastric cancer. Our finding shows that Cy can block the MET/AKT/mTOR axis by decreasing the phosphorylation level of AKT, mTOR and P70S6K. Therefore, the MET/AKT/mTOR axis may be an important target for Cy. In summary, Cy has anti-cancer properties and is expected to be a potential drug for the treatment of gastric cancer.
format	article
author	Juanli Ji Zhongze Wang Wei Sun Zekun Li Huarui Cai Erhu Zhao Hongjuan Cui
author_facet	Juanli Ji Zhongze Wang Wei Sun Zekun Li Huarui Cai Erhu Zhao Hongjuan Cui
author_sort	Juanli Ji
title	Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer
title_short	Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer
title_full	Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer
title_fullStr	Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer
title_full_unstemmed	Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer
title_sort	effects of cynaroside on cell proliferation, apoptosis, migration and invasion though the met/akt/mtor axis in gastric cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d896f5b362034d1abded7a55b9708b0e
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Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer

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