High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes

Salt, commonly known as sodium chloride, is an important ingredient that the body requires in relatively minute quantities. However, consuming too much salt can lead to high blood pressure, heart disease and even disruption of circadian rhythms. The biological process of the circadian rhythm was fir...

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Autores principales:	Xiaoyue Du, Lingqi Yu, Shengan Ling, Jiayu Xie, Wenfeng Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Drosophila</i> high salt diet neurons plasticity neurotransmitters Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d898fcd64574479ba785b516a8de746b
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spelling	oai:doaj.org-article:d898fcd64574479ba785b516a8de746b2021-11-25T18:36:56ZHigh-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes10.3390/nu131141232072-6643https://doaj.org/article/d898fcd64574479ba785b516a8de746b2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4123https://doaj.org/toc/2072-6643Salt, commonly known as sodium chloride, is an important ingredient that the body requires in relatively minute quantities. However, consuming too much salt can lead to high blood pressure, heart disease and even disruption of circadian rhythms. The biological process of the circadian rhythm was first studied in <i>Drosophila melanogaster</i> and is well understood. Their locomotor activity gradually increases before the light is switched on and off, a phenomenon called anticipation. In a previous study, we showed that a high-salt diet (HSD) impairs morning anticipation behavior in <i>Drosophila</i>. Here, we found that HSD did not significantly disrupt clock gene oscillation in the heads of flies, nor did it disrupt PERIOD protein oscillation in clock neurons or peripheral tissues. Remarkably, we found that HSD impairs neuronal plasticity in the axonal projections of circadian pacemaker neurons. Interestingly, we showed that increased excitability in PDF neurons mimics HSD, which causes morning anticipation impairment. Moreover, we found that HSD significantly disrupts neurotransmitter-related biological processes in the brain. Taken together, our data show that an HSD affects the multiple functions of neurons and impairs physiological behaviors.Xiaoyue DuLingqi YuShengan LingJiayu XieWenfeng ChenMDPI AGarticle<i>Drosophila</i>high salt dietneurons plasticityneurotransmittersNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4123, p 4123 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Drosophila</i> high salt diet neurons plasticity neurotransmitters Nutrition. Foods and food supply TX341-641
spellingShingle	<i>Drosophila</i> high salt diet neurons plasticity neurotransmitters Nutrition. Foods and food supply TX341-641 Xiaoyue Du Lingqi Yu Shengan Ling Jiayu Xie Wenfeng Chen High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes
description	Salt, commonly known as sodium chloride, is an important ingredient that the body requires in relatively minute quantities. However, consuming too much salt can lead to high blood pressure, heart disease and even disruption of circadian rhythms. The biological process of the circadian rhythm was first studied in <i>Drosophila melanogaster</i> and is well understood. Their locomotor activity gradually increases before the light is switched on and off, a phenomenon called anticipation. In a previous study, we showed that a high-salt diet (HSD) impairs morning anticipation behavior in <i>Drosophila</i>. Here, we found that HSD did not significantly disrupt clock gene oscillation in the heads of flies, nor did it disrupt PERIOD protein oscillation in clock neurons or peripheral tissues. Remarkably, we found that HSD impairs neuronal plasticity in the axonal projections of circadian pacemaker neurons. Interestingly, we showed that increased excitability in PDF neurons mimics HSD, which causes morning anticipation impairment. Moreover, we found that HSD significantly disrupts neurotransmitter-related biological processes in the brain. Taken together, our data show that an HSD affects the multiple functions of neurons and impairs physiological behaviors.
format	article
author	Xiaoyue Du Lingqi Yu Shengan Ling Jiayu Xie Wenfeng Chen
author_facet	Xiaoyue Du Lingqi Yu Shengan Ling Jiayu Xie Wenfeng Chen
author_sort	Xiaoyue Du
title	High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes
title_short	High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes
title_full	High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes
title_fullStr	High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes
title_full_unstemmed	High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes
title_sort	high-salt diet impairs the neurons plasticity and the neurotransmitters-related biological processes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d898fcd64574479ba785b516a8de746b
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High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes

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