Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

Migrating cells tune their energy utilization in response to their microenvironment, but how cellular energetics direct navigation remains unclear. Here, the authors report that energetic costs for motility, regulated by cell mechanics and confinement, predict the probability of migration choice.

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Autores principales:	Matthew R. Zanotelli, Aniqua Rahman-Zaman, Jacob A. VanderBurgh, Paul V. Taufalele, Aadhar Jain, David Erickson, Francois Bordeleau, Cynthia A. Reinhart-King
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d89947d85d604810a3c24366f9f1743c
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spelling	oai:doaj.org-article:d89947d85d604810a3c24366f9f1743c2021-12-02T15:36:17ZEnergetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making10.1038/s41467-019-12155-z2041-1723https://doaj.org/article/d89947d85d604810a3c24366f9f1743c2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12155-zhttps://doaj.org/toc/2041-1723Migrating cells tune their energy utilization in response to their microenvironment, but how cellular energetics direct navigation remains unclear. Here, the authors report that energetic costs for motility, regulated by cell mechanics and confinement, predict the probability of migration choice.Matthew R. ZanotelliAniqua Rahman-ZamanJacob A. VanderBurghPaul V. TaufaleleAadhar JainDavid EricksonFrancois BordeleauCynthia A. Reinhart-KingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew R. Zanotelli Aniqua Rahman-Zaman Jacob A. VanderBurgh Paul V. Taufalele Aadhar Jain David Erickson Francois Bordeleau Cynthia A. Reinhart-King Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
description	Migrating cells tune their energy utilization in response to their microenvironment, but how cellular energetics direct navigation remains unclear. Here, the authors report that energetic costs for motility, regulated by cell mechanics and confinement, predict the probability of migration choice.
format	article
author	Matthew R. Zanotelli Aniqua Rahman-Zaman Jacob A. VanderBurgh Paul V. Taufalele Aadhar Jain David Erickson Francois Bordeleau Cynthia A. Reinhart-King
author_facet	Matthew R. Zanotelli Aniqua Rahman-Zaman Jacob A. VanderBurgh Paul V. Taufalele Aadhar Jain David Erickson Francois Bordeleau Cynthia A. Reinhart-King
author_sort	Matthew R. Zanotelli
title	Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
title_short	Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
title_full	Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
title_fullStr	Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
title_full_unstemmed	Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
title_sort	energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d89947d85d604810a3c24366f9f1743c
work_keys_str_mv	AT matthewrzanotelli energeticcostsregulatedbycellmechanicsandconfinementarepredictiveofmigrationpathduringdecisionmaking AT aniquarahmanzaman energeticcostsregulatedbycellmechanicsandconfinementarepredictiveofmigrationpathduringdecisionmaking AT jacobavanderburgh energeticcostsregulatedbycellmechanicsandconfinementarepredictiveofmigrationpathduringdecisionmaking AT paulvtaufalele energeticcostsregulatedbycellmechanicsandconfinementarepredictiveofmigrationpathduringdecisionmaking AT aadharjain energeticcostsregulatedbycellmechanicsandconfinementarepredictiveofmigrationpathduringdecisionmaking AT daviderickson energeticcostsregulatedbycellmechanicsandconfinementarepredictiveofmigrationpathduringdecisionmaking AT francoisbordeleau energeticcostsregulatedbycellmechanicsandconfinementarepredictiveofmigrationpathduringdecisionmaking AT cynthiaareinhartking energeticcostsregulatedbycellmechanicsandconfinementarepredictiveofmigrationpathduringdecisionmaking
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Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

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