Potassium channel-based optogenetic silencing

Optogenetic tools enable precise experimental control of the behaviour of cells. Here, the authors introduce a genetically-encoded two-protein system that enables silencing of excitable cells such as neurons and cardiomyocytes using blue light, and demonstrate its utility both in vitro and In vivo.

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Autores principales:	Yinth Andrea Bernal Sierra, Benjamin R. Rost, Martin Pofahl, António Miguel Fernandes, Ramona A. Kopton, Sylvain Moser, Dominik Holtkamp, Nicola Masala, Prateep Beed, John J. Tukker, Silvia Oldani, Wolfgang Bönigk, Peter Kohl, Herwig Baier, Franziska Schneider-Warme, Peter Hegemann, Heinz Beck, Reinhard Seifert, Dietmar Schmitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8999362660741adba65546c0b941d4e
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spelling	oai:doaj.org-article:d8999362660741adba65546c0b941d4e2021-12-02T15:34:18ZPotassium channel-based optogenetic silencing10.1038/s41467-018-07038-82041-1723https://doaj.org/article/d8999362660741adba65546c0b941d4e2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07038-8https://doaj.org/toc/2041-1723Optogenetic tools enable precise experimental control of the behaviour of cells. Here, the authors introduce a genetically-encoded two-protein system that enables silencing of excitable cells such as neurons and cardiomyocytes using blue light, and demonstrate its utility both in vitro and In vivo.Yinth Andrea Bernal SierraBenjamin R. RostMartin PofahlAntónio Miguel FernandesRamona A. KoptonSylvain MoserDominik HoltkampNicola MasalaPrateep BeedJohn J. TukkerSilvia OldaniWolfgang BönigkPeter KohlHerwig BaierFranziska Schneider-WarmePeter HegemannHeinz BeckReinhard SeifertDietmar SchmitzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yinth Andrea Bernal Sierra Benjamin R. Rost Martin Pofahl António Miguel Fernandes Ramona A. Kopton Sylvain Moser Dominik Holtkamp Nicola Masala Prateep Beed John J. Tukker Silvia Oldani Wolfgang Bönigk Peter Kohl Herwig Baier Franziska Schneider-Warme Peter Hegemann Heinz Beck Reinhard Seifert Dietmar Schmitz Potassium channel-based optogenetic silencing
description	Optogenetic tools enable precise experimental control of the behaviour of cells. Here, the authors introduce a genetically-encoded two-protein system that enables silencing of excitable cells such as neurons and cardiomyocytes using blue light, and demonstrate its utility both in vitro and In vivo.
format	article
author	Yinth Andrea Bernal Sierra Benjamin R. Rost Martin Pofahl António Miguel Fernandes Ramona A. Kopton Sylvain Moser Dominik Holtkamp Nicola Masala Prateep Beed John J. Tukker Silvia Oldani Wolfgang Bönigk Peter Kohl Herwig Baier Franziska Schneider-Warme Peter Hegemann Heinz Beck Reinhard Seifert Dietmar Schmitz
author_facet	Yinth Andrea Bernal Sierra Benjamin R. Rost Martin Pofahl António Miguel Fernandes Ramona A. Kopton Sylvain Moser Dominik Holtkamp Nicola Masala Prateep Beed John J. Tukker Silvia Oldani Wolfgang Bönigk Peter Kohl Herwig Baier Franziska Schneider-Warme Peter Hegemann Heinz Beck Reinhard Seifert Dietmar Schmitz
author_sort	Yinth Andrea Bernal Sierra
title	Potassium channel-based optogenetic silencing
title_short	Potassium channel-based optogenetic silencing
title_full	Potassium channel-based optogenetic silencing
title_fullStr	Potassium channel-based optogenetic silencing
title_full_unstemmed	Potassium channel-based optogenetic silencing
title_sort	potassium channel-based optogenetic silencing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d8999362660741adba65546c0b941d4e
work_keys_str_mv	AT yinthandreabernalsierra potassiumchannelbasedoptogeneticsilencing AT benjaminrrost potassiumchannelbasedoptogeneticsilencing AT martinpofahl potassiumchannelbasedoptogeneticsilencing AT antoniomiguelfernandes potassiumchannelbasedoptogeneticsilencing AT ramonaakopton potassiumchannelbasedoptogeneticsilencing AT sylvainmoser potassiumchannelbasedoptogeneticsilencing AT dominikholtkamp potassiumchannelbasedoptogeneticsilencing AT nicolamasala potassiumchannelbasedoptogeneticsilencing AT prateepbeed potassiumchannelbasedoptogeneticsilencing AT johnjtukker potassiumchannelbasedoptogeneticsilencing AT silviaoldani potassiumchannelbasedoptogeneticsilencing AT wolfgangbonigk potassiumchannelbasedoptogeneticsilencing AT peterkohl potassiumchannelbasedoptogeneticsilencing AT herwigbaier potassiumchannelbasedoptogeneticsilencing AT franziskaschneiderwarme potassiumchannelbasedoptogeneticsilencing AT peterhegemann potassiumchannelbasedoptogeneticsilencing AT heinzbeck potassiumchannelbasedoptogeneticsilencing AT reinhardseifert potassiumchannelbasedoptogeneticsilencing AT dietmarschmitz potassiumchannelbasedoptogeneticsilencing
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Potassium channel-based optogenetic silencing

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