Medication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model

Background: The number of patients with type 2 diabetes (T2D) is increasing. Medication treatment is of great importance to stabilize blood glucose. Previous studies have reported that neuroticism, self-efficacy, and social support are factors associated with medication adherence, but few studies ha...

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Autores principales:	Jing Huang, Shenglan Ding, Shuyuan Xiong, Zhiping Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neuroticism social support self-efficacy medication adherence type 2 diabetes structural equation model Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/d8a05f1becff49bcb289b3db0e1aa0bb
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spelling	oai:doaj.org-article:d8a05f1becff49bcb289b3db0e1aa0bb2021-11-04T05:41:17ZMedication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model2296-256510.3389/fpubh.2021.730845https://doaj.org/article/d8a05f1becff49bcb289b3db0e1aa0bb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.730845/fullhttps://doaj.org/toc/2296-2565Background: The number of patients with type 2 diabetes (T2D) is increasing. Medication treatment is of great importance to stabilize blood glucose. Previous studies have reported that neuroticism, self-efficacy, and social support are factors associated with medication adherence, but few studies have fully investigated the mechanisms between these factors and medication adherence in patients with T2D.Purpose: To explore the prevalence of medication adherence and the factors associated with medication adherence in patients with T2D.Methods: A cross-sectional study consisting of 483 patients with T2D was conducted from July to December 2020. Questionnaires containing sociodemographic and clinical characteristics, the Morisky Medication Adherence Scale-8 (MMAS-8), the neuroticism subscale of the Eysenck Personality Questionnaire-Revised Short Scale (EPQ-RS), the Multidimensional Scale of Perceived Social Support (MSPSS), and the Diabetes Management Self-efficacy Scale (DMSES) were used to collect data. The structural equation model (SEM) was used to test the hypotheses.Results: This study included 305 (63.1%) medication adherence and 178 (36.9%) medication non-adherence patients with T2D. Social support directly influenced medication adherence (β = 0.115, P = 0.029) and indirectly influenced medication adherence through self-efficacy (β = 0.044, P = 0.016). Self-efficacy directly influenced medication adherence (β = 0.139, P = 0.023). Neuroticism indirectly affected medication adherence through social support (β = −0.027, P = 0.023) and self-efficacy (β = −0.019, P = 0.014). Moreover, there was a sequential mediating effect of social support and self-efficacy on the relationship between neuroticism and medication adherence (β = −0.010, P = 0.012). After controlling for age and gender, similar results were obtained. The model fit indices showed a good fit.Conclusions: The medication adherence of patients with T2D needs to be improved. Neuroticism, social support, and self-efficacy had direct or indirect effects on medication adherence in patients with T2D. Healthcare providers should comprehensively develop intervention programs based on neuroticism, social support, and self-efficacy to improve medication adherence in patients with T2D.Jing HuangShenglan DingShuyuan XiongZhiping LiuFrontiers Media S.A.articleneuroticismsocial supportself-efficacymedication adherencetype 2 diabetesstructural equation modelPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroticism social support self-efficacy medication adherence type 2 diabetes structural equation model Public aspects of medicine RA1-1270
spellingShingle	neuroticism social support self-efficacy medication adherence type 2 diabetes structural equation model Public aspects of medicine RA1-1270 Jing Huang Shenglan Ding Shuyuan Xiong Zhiping Liu Medication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model
description	Background: The number of patients with type 2 diabetes (T2D) is increasing. Medication treatment is of great importance to stabilize blood glucose. Previous studies have reported that neuroticism, self-efficacy, and social support are factors associated with medication adherence, but few studies have fully investigated the mechanisms between these factors and medication adherence in patients with T2D.Purpose: To explore the prevalence of medication adherence and the factors associated with medication adherence in patients with T2D.Methods: A cross-sectional study consisting of 483 patients with T2D was conducted from July to December 2020. Questionnaires containing sociodemographic and clinical characteristics, the Morisky Medication Adherence Scale-8 (MMAS-8), the neuroticism subscale of the Eysenck Personality Questionnaire-Revised Short Scale (EPQ-RS), the Multidimensional Scale of Perceived Social Support (MSPSS), and the Diabetes Management Self-efficacy Scale (DMSES) were used to collect data. The structural equation model (SEM) was used to test the hypotheses.Results: This study included 305 (63.1%) medication adherence and 178 (36.9%) medication non-adherence patients with T2D. Social support directly influenced medication adherence (β = 0.115, P = 0.029) and indirectly influenced medication adherence through self-efficacy (β = 0.044, P = 0.016). Self-efficacy directly influenced medication adherence (β = 0.139, P = 0.023). Neuroticism indirectly affected medication adherence through social support (β = −0.027, P = 0.023) and self-efficacy (β = −0.019, P = 0.014). Moreover, there was a sequential mediating effect of social support and self-efficacy on the relationship between neuroticism and medication adherence (β = −0.010, P = 0.012). After controlling for age and gender, similar results were obtained. The model fit indices showed a good fit.Conclusions: The medication adherence of patients with T2D needs to be improved. Neuroticism, social support, and self-efficacy had direct or indirect effects on medication adherence in patients with T2D. Healthcare providers should comprehensively develop intervention programs based on neuroticism, social support, and self-efficacy to improve medication adherence in patients with T2D.
format	article
author	Jing Huang Shenglan Ding Shuyuan Xiong Zhiping Liu
author_facet	Jing Huang Shenglan Ding Shuyuan Xiong Zhiping Liu
author_sort	Jing Huang
title	Medication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model
title_short	Medication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model
title_full	Medication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model
title_fullStr	Medication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model
title_full_unstemmed	Medication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model
title_sort	medication adherence and associated factors in patients with type 2 diabetes: a structural equation model
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d8a05f1becff49bcb289b3db0e1aa0bb
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Medication Adherence and Associated Factors in Patients With Type 2 Diabetes: A Structural Equation Model

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