Delivered growth factor therapy to improve healing after rotator cuff repair

Emilie V Cheung, Luz Silverio, Jeffrey YaoDepartment of Orthopedic Surgery, Stanford University, Redwood City, CA, USABackground: Degenerative rotator cuff tears are a significant cause of shoulder pain in the aging population. Rotator cuff repair surgery may be more successful when growth factors a...

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Autores principales:	Emilie V Cheung, Luz Silverio, Jeffrey Yao
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/d8a06f840f6a466bb9dbda19f81d8fe0
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spelling	oai:doaj.org-article:d8a06f840f6a466bb9dbda19f81d8fe02021-12-02T02:41:24ZDelivered growth factor therapy to improve healing after rotator cuff repair1178-6957https://doaj.org/article/d8a06f840f6a466bb9dbda19f81d8fe02010-10-01T00:00:00Zhttp://www.dovepress.com/delivered-growth-factor-therapy-to-improve-healing-after-rotator-cuff--a5470https://doaj.org/toc/1178-6957Emilie V Cheung, Luz Silverio, Jeffrey YaoDepartment of Orthopedic Surgery, Stanford University, Redwood City, CA, USABackground: Degenerative rotator cuff tears are a significant cause of shoulder pain in the aging population. Rotator cuff repair surgery may be more successful when growth factors are delivered to the repair site. This study was designed to determine the cellular processes involved in normal bone-to-tendon healing and the current approaches used for biologic augmentation of rotator cuff repair.Methods: This review focuses on animal studies of rotator cuff repair and early human trials.Results: Regular bone-to-tendon healing forms a fibrous junction between tendon and bone that is markedly different from the original bone-to-tendon junction. Tendon augmentation with cellular components serves as scaffolding for endogenous fibroblastic cells and a possible source of growth factors and fibroblastic cells. Extracellular matrices provide a scaffold for incoming fibroblastic cells. However, research in extracellular matrices is not conclusive due to intermanufacturer variation and the lack of human subject research. Growth factors and platelet-rich plasma are established in other fields of research and show promise, but have not yet been rigorously tested in rotator cuff repair augmentation.Conclusions: Rotator cuff repair can benefit from biologic augmentation. However, research in this field is still young and has not yet demonstrated that the benefits in healing rates are significant enough to merit regular clinical use. Randomized controlled trials will elucidate the use of biologic augmentation in rotator cuff repairs.Keywords: rotator cuff, shoulder pain, growth factors, repair Emilie V CheungLuz SilverioJeffrey YaoDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2010, Iss default, Pp 135-144 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Emilie V Cheung Luz Silverio Jeffrey Yao Delivered growth factor therapy to improve healing after rotator cuff repair
description	Emilie V Cheung, Luz Silverio, Jeffrey YaoDepartment of Orthopedic Surgery, Stanford University, Redwood City, CA, USABackground: Degenerative rotator cuff tears are a significant cause of shoulder pain in the aging population. Rotator cuff repair surgery may be more successful when growth factors are delivered to the repair site. This study was designed to determine the cellular processes involved in normal bone-to-tendon healing and the current approaches used for biologic augmentation of rotator cuff repair.Methods: This review focuses on animal studies of rotator cuff repair and early human trials.Results: Regular bone-to-tendon healing forms a fibrous junction between tendon and bone that is markedly different from the original bone-to-tendon junction. Tendon augmentation with cellular components serves as scaffolding for endogenous fibroblastic cells and a possible source of growth factors and fibroblastic cells. Extracellular matrices provide a scaffold for incoming fibroblastic cells. However, research in extracellular matrices is not conclusive due to intermanufacturer variation and the lack of human subject research. Growth factors and platelet-rich plasma are established in other fields of research and show promise, but have not yet been rigorously tested in rotator cuff repair augmentation.Conclusions: Rotator cuff repair can benefit from biologic augmentation. However, research in this field is still young and has not yet demonstrated that the benefits in healing rates are significant enough to merit regular clinical use. Randomized controlled trials will elucidate the use of biologic augmentation in rotator cuff repairs.Keywords: rotator cuff, shoulder pain, growth factors, repair
format	article
author	Emilie V Cheung Luz Silverio Jeffrey Yao
author_facet	Emilie V Cheung Luz Silverio Jeffrey Yao
author_sort	Emilie V Cheung
title	Delivered growth factor therapy to improve healing after rotator cuff repair
title_short	Delivered growth factor therapy to improve healing after rotator cuff repair
title_full	Delivered growth factor therapy to improve healing after rotator cuff repair
title_fullStr	Delivered growth factor therapy to improve healing after rotator cuff repair
title_full_unstemmed	Delivered growth factor therapy to improve healing after rotator cuff repair
title_sort	delivered growth factor therapy to improve healing after rotator cuff repair
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/d8a06f840f6a466bb9dbda19f81d8fe0
work_keys_str_mv	AT emilievcheung deliveredgrowthfactortherapytoimprovehealingafterrotatorcuffrepair AT luzsilverio deliveredgrowthfactortherapytoimprovehealingafterrotatorcuffrepair AT jeffreyyao deliveredgrowthfactortherapytoimprovehealingafterrotatorcuffrepair
_version_	1718402318458683392

Delivered growth factor therapy to improve healing after rotator cuff repair

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