RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae

Small regulatory RNAs (sRNAs) in Vibrio cholerae have been shown to modulate several biological processess including virulence, biofilm formation, quorum sensing, colony morphology and stress resistance. Here, the authors show that VadR sRNA acts as a posttranscriptional inhibitor of the crvA mRNA a...

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Autores principales:	Nikolai Peschek, Roman Herzog, Praveen K. Singh, Marcel Sprenger, Fabian Meyer, Kathrin S. Fröhlich, Luise Schröger, Marc Bramkamp, Knut Drescher, Kai Papenfort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8a2c23274324db5add1e0da53a93899
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spelling	oai:doaj.org-article:d8a2c23274324db5add1e0da53a938992021-12-02T16:56:32ZRNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae10.1038/s41467-020-19890-82041-1723https://doaj.org/article/d8a2c23274324db5add1e0da53a938992020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19890-8https://doaj.org/toc/2041-1723Small regulatory RNAs (sRNAs) in Vibrio cholerae have been shown to modulate several biological processess including virulence, biofilm formation, quorum sensing, colony morphology and stress resistance. Here, the authors show that VadR sRNA acts as a posttranscriptional inhibitor of the crvA mRNA and that mutation of vadR increases cell curvature, whereas overexpression has the inverse effect.Nikolai PeschekRoman HerzogPraveen K. SinghMarcel SprengerFabian MeyerKathrin S. FröhlichLuise SchrögerMarc BramkampKnut DrescherKai PapenfortNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolai Peschek Roman Herzog Praveen K. Singh Marcel Sprenger Fabian Meyer Kathrin S. Fröhlich Luise Schröger Marc Bramkamp Knut Drescher Kai Papenfort RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae
description	Small regulatory RNAs (sRNAs) in Vibrio cholerae have been shown to modulate several biological processess including virulence, biofilm formation, quorum sensing, colony morphology and stress resistance. Here, the authors show that VadR sRNA acts as a posttranscriptional inhibitor of the crvA mRNA and that mutation of vadR increases cell curvature, whereas overexpression has the inverse effect.
format	article
author	Nikolai Peschek Roman Herzog Praveen K. Singh Marcel Sprenger Fabian Meyer Kathrin S. Fröhlich Luise Schröger Marc Bramkamp Knut Drescher Kai Papenfort
author_facet	Nikolai Peschek Roman Herzog Praveen K. Singh Marcel Sprenger Fabian Meyer Kathrin S. Fröhlich Luise Schröger Marc Bramkamp Knut Drescher Kai Papenfort
author_sort	Nikolai Peschek
title	RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae
title_short	RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae
title_full	RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae
title_fullStr	RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae
title_full_unstemmed	RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae
title_sort	rna-mediated control of cell shape modulates antibiotic resistance in vibrio cholerae
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d8a2c23274324db5add1e0da53a93899
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RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae

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