Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study

BackgroundNew data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Håkon Ihle‐Hansen, Thea Vigen, Hege Ihle‐Hansen, Ole Morten Rønning, Trygve Berge, Bente Thommessen, Magnus Nakrem Lyngbakken, Eivind Bjørkan Orstad, Steve Enger, Ståle Nygård, Helge Røsjø, Arnljot Tveit
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2018
Materias:	atherosclerosis cardiovascular disease carotid artery carotid ultrasound Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/d8a2d85d24ad4ed8a2fe657327530ac0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d8a2d85d24ad4ed8a2fe657327530ac0
record_format	dspace
spelling	oai:doaj.org-article:d8a2d85d24ad4ed8a2fe657327530ac02021-11-12T17:02:01ZPrevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study10.1161/JAHA.118.0085622047-9980https://doaj.org/article/d8a2d85d24ad4ed8a2fe657327530ac02018-05-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.118.008562https://doaj.org/toc/2047-9980BackgroundNew data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall disease and actual prevalence of established cardiovascular disease. We investigated the prevalence of atherosclerotic carotid plaques and carotid intima–media thickness (cIMT) and their relation to cardiovascular risk factors in a middle‐aged cohort from the general population. Methods and ResultsWe performed carotid ultrasound in 3683 participants who were born in 1950 and included in a population‐based Norwegian study. Carotid plaque and cIMT were assessed according to the Mannheim Carotid Intima–Media Thickness and Plaque Consensus, and a carotid plaque score was used to calculate atherosclerotic burden. The participants were aged 63 to 65 years, and 49% were women. The prevalence of established cardiovascular disease was low (10%), but 62% had hypertension, 53% had hypercholesterolemia, 11% had diabetes mellitus, and 23% were obese. Mean cIMT was 0.73±0.11 mm, and atherosclerotic carotid plaques were present in 87% of the participants (median plaque score: 2; interquartile range: 3). Most of the cardiovascular risk factors, with the exception of diabetes mellitus, obesity and waist–hip ratio, were independently associated with the plaque score. In contrast, only sex, hypertension, obesity, current smoking, and cerebrovascular disease were associated with cIMT. ConclusionsWe found very high prevalence of carotid plaque in this middle‐aged population, and our data support a greater association between cardiovascular risk factors and plaque burden, compared with cIMT. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01555411.Håkon Ihle‐HansenThea VigenHege Ihle‐HansenOle Morten RønningTrygve BergeBente ThommessenMagnus Nakrem LyngbakkenEivind Bjørkan OrstadSteve EngerStåle NygårdHelge RøsjøArnljot TveitWileyarticleatherosclerosiscardiovascular diseasecarotid arterycarotid ultrasoundDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis cardiovascular disease carotid artery carotid ultrasound Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	atherosclerosis cardiovascular disease carotid artery carotid ultrasound Diseases of the circulatory (Cardiovascular) system RC666-701 Håkon Ihle‐Hansen Thea Vigen Hege Ihle‐Hansen Ole Morten Rønning Trygve Berge Bente Thommessen Magnus Nakrem Lyngbakken Eivind Bjørkan Orstad Steve Enger Ståle Nygård Helge Røsjø Arnljot Tveit Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study
description	BackgroundNew data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall disease and actual prevalence of established cardiovascular disease. We investigated the prevalence of atherosclerotic carotid plaques and carotid intima–media thickness (cIMT) and their relation to cardiovascular risk factors in a middle‐aged cohort from the general population. Methods and ResultsWe performed carotid ultrasound in 3683 participants who were born in 1950 and included in a population‐based Norwegian study. Carotid plaque and cIMT were assessed according to the Mannheim Carotid Intima–Media Thickness and Plaque Consensus, and a carotid plaque score was used to calculate atherosclerotic burden. The participants were aged 63 to 65 years, and 49% were women. The prevalence of established cardiovascular disease was low (10%), but 62% had hypertension, 53% had hypercholesterolemia, 11% had diabetes mellitus, and 23% were obese. Mean cIMT was 0.73±0.11 mm, and atherosclerotic carotid plaques were present in 87% of the participants (median plaque score: 2; interquartile range: 3). Most of the cardiovascular risk factors, with the exception of diabetes mellitus, obesity and waist–hip ratio, were independently associated with the plaque score. In contrast, only sex, hypertension, obesity, current smoking, and cerebrovascular disease were associated with cIMT. ConclusionsWe found very high prevalence of carotid plaque in this middle‐aged population, and our data support a greater association between cardiovascular risk factors and plaque burden, compared with cIMT. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01555411.
format	article
author	Håkon Ihle‐Hansen Thea Vigen Hege Ihle‐Hansen Ole Morten Rønning Trygve Berge Bente Thommessen Magnus Nakrem Lyngbakken Eivind Bjørkan Orstad Steve Enger Ståle Nygård Helge Røsjø Arnljot Tveit
author_facet	Håkon Ihle‐Hansen Thea Vigen Hege Ihle‐Hansen Ole Morten Rønning Trygve Berge Bente Thommessen Magnus Nakrem Lyngbakken Eivind Bjørkan Orstad Steve Enger Ståle Nygård Helge Røsjø Arnljot Tveit
author_sort	Håkon Ihle‐Hansen
title	Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study
title_short	Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study
title_full	Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study
title_fullStr	Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study
title_full_unstemmed	Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study
title_sort	prevalence of carotid plaque in a 63‐ to 65‐year‐old norwegian cohort from the general population: the <styled-content style="fixed-case">ace</styled-content> (akershus cardiac examination) 1950 study
publisher	Wiley
publishDate	2018
url	https://doaj.org/article/d8a2d85d24ad4ed8a2fe657327530ac0
work_keys_str_mv	AT hakonihlehansen prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT theavigen prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT hegeihlehansen prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT olemortenrønning prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT trygveberge prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT bentethommessen prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT magnusnakremlyngbakken prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT eivindbjørkanorstad prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT steveenger prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT stalenygard prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT helgerøsjø prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study AT arnljottveit prevalenceofcarotidplaqueina63to65yearoldnorwegiancohortfromthegeneralpopulationthestyledcontentstylefixedcaseacestyledcontentakershuscardiacexamination1950study
_version_	1718430402100592640

Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The <styled-content style="fixed-case">ACE</styled-content> (Akershus Cardiac Examination) 1950 Study

Ejemplares similares