Endocrine Disorders Induced by PD-1/PD-L1 Inhibitor and Related Treatment

Immune checkpoint therapy is a new mode of tumor therapy. At present, many kinds of PD-1/PD-L1 inhibitors have been approved for clinical application on various tumors, such as malignant melanoma, lung cancer, bladder cancer, lymphoma, etc. However, with the gradual promotion and application in clin...

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Autores principales: LAI Yanliang, GENG Yan, YANG Bingquan
Formato: article
Lenguaje:ZH
Publicado: Magazine House of Cancer Research on Prevention and Treatment 2021
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Acceso en línea:https://doaj.org/article/d8ae6841853849339273588500c2bc99
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Sumario:Immune checkpoint therapy is a new mode of tumor therapy. At present, many kinds of PD-1/PD-L1 inhibitors have been approved for clinical application on various tumors, such as malignant melanoma, lung cancer, bladder cancer, lymphoma, etc. However, with the gradual promotion and application in clinical practice, various immune-related adverse reactions caused by PD-1/PD-L1 inhibitors have attracted extensive attention. Especially in recent years, a number of adverse reactions related to endocrine gland injury have been reported. This paper reviews the research status and corresponding clinical treatment methods of endocrine gland related adverse reactions caused by PD-1/PD-L1 inhibitors.