Comparison of various synthesis methods and synthesis parameters of pyrazoline derivates
Pyrazoline plays an important role in the development of heterocyclic chemistry theory and is widely used as a synthesis useful in organic synthesis. The structure of the pyrazoline derivative compound contains a 5-membered heterocyclic framework with two nitrogen atoms and one endocyclic double bon...
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Wolters Kluwer Medknow Publications
2021
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oai:doaj.org-article:d8b29d8a9691435199dc3bd3f3d09ab82021-11-12T10:17:53ZComparison of various synthesis methods and synthesis parameters of pyrazoline derivates2231-40400976-209410.4103/japtr.JAPTR_252_21https://doaj.org/article/d8b29d8a9691435199dc3bd3f3d09ab82021-01-01T00:00:00Zhttp://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=4;spage=321;epage=326;aulast=Pracekahttps://doaj.org/toc/2231-4040https://doaj.org/toc/0976-2094Pyrazoline plays an important role in the development of heterocyclic chemistry theory and is widely used as a synthesis useful in organic synthesis. The structure of the pyrazoline derivative compound contains a 5-membered heterocyclic framework with two nitrogen atoms and one endocyclic double bond. The function of pyrazoline as a fragment was stable enough in the bioactive group to synthesize new compounds with various biological activities. Various methods that could be used for the synthesis of pyrazole derivatives were ultrasonic irradiation, microwave assistance, ionic liquids, grinding techniques, and conventional methods. However, the synthesis of pyrazoline derivatives using conventional methods had many problems, one of which is the product yield, which was <70%. Therefore, this article will discuss the importance of optimizing the synthesis reaction conditions by taking into account several synthesis parameters to get the best organic product results based on conventional methods. A literature search was conducted by employing PubChem, Chemspider Google Scholar, Research Gate, Science Direct, and Elsevier by selecting pyrazoline synthesis based on physicochemical profile, reaction mechanism, and synthesis method.Meilinda Setya PracekaSandra MegantaraRani MaharaniMuchtaridi MuchtaridiWolters Kluwer Medknow Publicationsarticleparameter synthesispyrazoline derivatessynthesis methodsTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Advanced Pharmaceutical Technology & Research, Vol 12, Iss 4, Pp 321-326 (2021) |
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parameter synthesis pyrazoline derivates synthesis methods Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 |
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parameter synthesis pyrazoline derivates synthesis methods Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Meilinda Setya Praceka Sandra Megantara Rani Maharani Muchtaridi Muchtaridi Comparison of various synthesis methods and synthesis parameters of pyrazoline derivates |
| description |
Pyrazoline plays an important role in the development of heterocyclic chemistry theory and is widely used as a synthesis useful in organic synthesis. The structure of the pyrazoline derivative compound contains a 5-membered heterocyclic framework with two nitrogen atoms and one endocyclic double bond. The function of pyrazoline as a fragment was stable enough in the bioactive group to synthesize new compounds with various biological activities. Various methods that could be used for the synthesis of pyrazole derivatives were ultrasonic irradiation, microwave assistance, ionic liquids, grinding techniques, and conventional methods. However, the synthesis of pyrazoline derivatives using conventional methods had many problems, one of which is the product yield, which was <70%. Therefore, this article will discuss the importance of optimizing the synthesis reaction conditions by taking into account several synthesis parameters to get the best organic product results based on conventional methods. A literature search was conducted by employing PubChem, Chemspider Google Scholar, Research Gate, Science Direct, and Elsevier by selecting pyrazoline synthesis based on physicochemical profile, reaction mechanism, and synthesis method. |
| format |
article |
| author |
Meilinda Setya Praceka Sandra Megantara Rani Maharani Muchtaridi Muchtaridi |
| author_facet |
Meilinda Setya Praceka Sandra Megantara Rani Maharani Muchtaridi Muchtaridi |
| author_sort |
Meilinda Setya Praceka |
| title |
Comparison of various synthesis methods and synthesis parameters of pyrazoline derivates |
| title_short |
Comparison of various synthesis methods and synthesis parameters of pyrazoline derivates |
| title_full |
Comparison of various synthesis methods and synthesis parameters of pyrazoline derivates |
| title_fullStr |
Comparison of various synthesis methods and synthesis parameters of pyrazoline derivates |
| title_full_unstemmed |
Comparison of various synthesis methods and synthesis parameters of pyrazoline derivates |
| title_sort |
comparison of various synthesis methods and synthesis parameters of pyrazoline derivates |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2021 |
| url |
https://doaj.org/article/d8b29d8a9691435199dc3bd3f3d09ab8 |
| work_keys_str_mv |
AT meilindasetyapraceka comparisonofvarioussynthesismethodsandsynthesisparametersofpyrazolinederivates AT sandramegantara comparisonofvarioussynthesismethodsandsynthesisparametersofpyrazolinederivates AT ranimaharani comparisonofvarioussynthesismethodsandsynthesisparametersofpyrazolinederivates AT muchtaridimuchtaridi comparisonofvarioussynthesismethodsandsynthesisparametersofpyrazolinederivates |
| _version_ |
1718431021908623360 |