Risky decision-making following prefrontal D1 receptor manipulation

The prefrontal dopamine D1 receptor (D1R) is involved in cognitive processes. Viral overexpression of this receptor in rats further increases the reward-related behaviors and even its termination induces anhedonia and helplessness. In this study, we investigated the risky decision-making during D1R...

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Autores principales:	Beyer Dominik K. E., Horn Lisa, Klinker Nadine, Freund Nadja
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	iowa gambling task lentivirus rat bipolar disorder mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/d8b6025198f04cd7aec70137d27b77b0
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spelling	oai:doaj.org-article:d8b6025198f04cd7aec70137d27b77b02021-12-05T14:11:05ZRisky decision-making following prefrontal D1 receptor manipulation2081-693610.1515/tnsci-2020-0187https://doaj.org/article/d8b6025198f04cd7aec70137d27b77b02021-11-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0187https://doaj.org/toc/2081-6936The prefrontal dopamine D1 receptor (D1R) is involved in cognitive processes. Viral overexpression of this receptor in rats further increases the reward-related behaviors and even its termination induces anhedonia and helplessness. In this study, we investigated the risky decision-making during D1R overexpression and its termination. Rats conducted the rodent version of the Iowa gambling task daily. In addition, the methyl CpG–binding protein-2 (MeCP2), one regulator connecting the dopaminergic system, cognitive processes, and mood-related behavior, was investigated after completion of the behavioral tasks. D1R overexpressing subjects exhibited maladaptive risky decision-making and risky decisions returned to control levels following termination of D1R overexpression; however, after termination, animals earned less reward compared to control subjects. In this phase, MeCP2-positive cells were elevated in the right amygdala. Our results extend the previously reported behavioral changes in the D1R-manipulated animal model to increased risk-taking and revealed differential MeCP2 expression adding further evidence for a bipolar disorder-like phenotype of this model.Beyer Dominik K. E.Horn LisaKlinker NadineFreund NadjaDe Gruyterarticleiowa gambling tasklentivirusratbipolar disordermaniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 432-443 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	iowa gambling task lentivirus rat bipolar disorder mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	iowa gambling task lentivirus rat bipolar disorder mania Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Beyer Dominik K. E. Horn Lisa Klinker Nadine Freund Nadja Risky decision-making following prefrontal D1 receptor manipulation
description	The prefrontal dopamine D1 receptor (D1R) is involved in cognitive processes. Viral overexpression of this receptor in rats further increases the reward-related behaviors and even its termination induces anhedonia and helplessness. In this study, we investigated the risky decision-making during D1R overexpression and its termination. Rats conducted the rodent version of the Iowa gambling task daily. In addition, the methyl CpG–binding protein-2 (MeCP2), one regulator connecting the dopaminergic system, cognitive processes, and mood-related behavior, was investigated after completion of the behavioral tasks. D1R overexpressing subjects exhibited maladaptive risky decision-making and risky decisions returned to control levels following termination of D1R overexpression; however, after termination, animals earned less reward compared to control subjects. In this phase, MeCP2-positive cells were elevated in the right amygdala. Our results extend the previously reported behavioral changes in the D1R-manipulated animal model to increased risk-taking and revealed differential MeCP2 expression adding further evidence for a bipolar disorder-like phenotype of this model.
format	article
author	Beyer Dominik K. E. Horn Lisa Klinker Nadine Freund Nadja
author_facet	Beyer Dominik K. E. Horn Lisa Klinker Nadine Freund Nadja
author_sort	Beyer Dominik K. E.
title	Risky decision-making following prefrontal D1 receptor manipulation
title_short	Risky decision-making following prefrontal D1 receptor manipulation
title_full	Risky decision-making following prefrontal D1 receptor manipulation
title_fullStr	Risky decision-making following prefrontal D1 receptor manipulation
title_full_unstemmed	Risky decision-making following prefrontal D1 receptor manipulation
title_sort	risky decision-making following prefrontal d1 receptor manipulation
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/d8b6025198f04cd7aec70137d27b77b0
work_keys_str_mv	AT beyerdominikke riskydecisionmakingfollowingprefrontald1receptormanipulation AT hornlisa riskydecisionmakingfollowingprefrontald1receptormanipulation AT klinkernadine riskydecisionmakingfollowingprefrontald1receptormanipulation AT freundnadja riskydecisionmakingfollowingprefrontald1receptormanipulation
_version_	1718371447730077696

Risky decision-making following prefrontal D1 receptor manipulation

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