Vitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients

Objectives: Vascular calcification is common in patients with advanced chronic kidney disease (CKD) and contributes to cardiovascular disease. Accumulating evidence indicates that CKD patients often acquire subclinical vitamin K deficiency, which is associated with vascular calcification. Methods...

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Autores principales:	Shoya Oyama, Naoki Okamoto, Shigehisa Koide, Hiroki Hayashi, Shigeru Nakai, Kazuo Takahashi, Daijo Inaguma, Midori Hasegawa, Hiroshi Toyama, Satoshi Sugiyama, Yukio Yuzawa, Naotake Tsuboi
Formato:	article
Lenguaje:	EN
Publicado:	Fujita Medical Society 2021
Materias:	vitamin k aortic abdominal calcification dialysis randomized control trial agatston score Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d8b6695d48c145f498234b20938bba95
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spelling	oai:doaj.org-article:d8b6695d48c145f498234b20938bba952021-11-10T04:38:28ZVitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients10.20407/fmj.2020-0202189-72472189-7255https://doaj.org/article/d8b6695d48c145f498234b20938bba952021-11-01T00:00:00Zhttps://www.jstage.jst.go.jp/article/fmj/7/4/7_2020-020/_pdf/-char/enhttps://doaj.org/toc/2189-7247https://doaj.org/toc/2189-7255Objectives: Vascular calcification is common in patients with advanced chronic kidney disease (CKD) and contributes to cardiovascular disease. Accumulating evidence indicates that CKD patients often acquire subclinical vitamin K deficiency, which is associated with vascular calcification. Methods: This prospective, randomized, parallel group, multicenter trial (UMINID000011490) will include 200 dialysis patients in an open-label, two-arm design. After baseline computed tomography of the abdominal aorta, patients will be randomized to two groups that will either (1) continue receiving standard care or (2) receive additional oral supplementation with menatetrenone (45 mg/day). The treatment duration will be 24 months, and the computed tomography scan will be repeated after 12 and 24 months. The primary endpoint is the progression of abdominal aortic calcification, which is calculated as absolute changes based on the Agatston score. The secondary endpoints are the decrease in bone mineral density (measured by dual-energy X-ray absorptiometry), the biomarkers associated with vitamin K, vitamin K intake (evaluated by the food frequency questionnaire), and the biomarkers associated with vascular calcification. Conclusions: This study aims to confirm whether vitamin K has inhibitory effects on calcification that can be clinically determined. Trial registration: UMINID000011490.Shoya OyamaNaoki OkamotoShigehisa KoideHiroki HayashiShigeru NakaiKazuo TakahashiDaijo InagumaMidori HasegawaHiroshi ToyamaSatoshi SugiyamaYukio YuzawaNaotake TsuboiFujita Medical Societyarticlevitamin kaortic abdominal calcificationdialysisrandomized control trialagatston scoreMedicine (General)R5-920ENFujita Medical Journal, Vol 7, Iss 4, Pp 136-138 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin k aortic abdominal calcification dialysis randomized control trial agatston score Medicine (General) R5-920
spellingShingle	vitamin k aortic abdominal calcification dialysis randomized control trial agatston score Medicine (General) R5-920 Shoya Oyama Naoki Okamoto Shigehisa Koide Hiroki Hayashi Shigeru Nakai Kazuo Takahashi Daijo Inaguma Midori Hasegawa Hiroshi Toyama Satoshi Sugiyama Yukio Yuzawa Naotake Tsuboi Vitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients
description	Objectives: Vascular calcification is common in patients with advanced chronic kidney disease (CKD) and contributes to cardiovascular disease. Accumulating evidence indicates that CKD patients often acquire subclinical vitamin K deficiency, which is associated with vascular calcification. Methods: This prospective, randomized, parallel group, multicenter trial (UMINID000011490) will include 200 dialysis patients in an open-label, two-arm design. After baseline computed tomography of the abdominal aorta, patients will be randomized to two groups that will either (1) continue receiving standard care or (2) receive additional oral supplementation with menatetrenone (45 mg/day). The treatment duration will be 24 months, and the computed tomography scan will be repeated after 12 and 24 months. The primary endpoint is the progression of abdominal aortic calcification, which is calculated as absolute changes based on the Agatston score. The secondary endpoints are the decrease in bone mineral density (measured by dual-energy X-ray absorptiometry), the biomarkers associated with vitamin K, vitamin K intake (evaluated by the food frequency questionnaire), and the biomarkers associated with vascular calcification. Conclusions: This study aims to confirm whether vitamin K has inhibitory effects on calcification that can be clinically determined. Trial registration: UMINID000011490.
format	article
author	Shoya Oyama Naoki Okamoto Shigehisa Koide Hiroki Hayashi Shigeru Nakai Kazuo Takahashi Daijo Inaguma Midori Hasegawa Hiroshi Toyama Satoshi Sugiyama Yukio Yuzawa Naotake Tsuboi
author_facet	Shoya Oyama Naoki Okamoto Shigehisa Koide Hiroki Hayashi Shigeru Nakai Kazuo Takahashi Daijo Inaguma Midori Hasegawa Hiroshi Toyama Satoshi Sugiyama Yukio Yuzawa Naotake Tsuboi
author_sort	Shoya Oyama
title	Vitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients
title_short	Vitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients
title_full	Vitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients
title_fullStr	Vitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients
title_full_unstemmed	Vitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients
title_sort	vitamin k2 supplementation and the progression of abdominal aortic calcification in dialysis patients
publisher	Fujita Medical Society
publishDate	2021
url	https://doaj.org/article/d8b6695d48c145f498234b20938bba95
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Vitamin K2 supplementation and the progression of abdominal aortic calcification in dialysis patients

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